{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:09Z","timestamp":1777727349613,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Technology Development Project of Jilin Province","award":["#3D5197434429 and 2021LC019"],"award-info":[{"award-number":["#3D5197434429 and 2021LC019"]}]},{"name":"Youth Program of the National Natural Science Foundation of China","award":["#3A4205367429"],"award-info":[{"award-number":["#3A4205367429"]}]},{"name":"Education Project of Jilin University","award":["#419070600046"],"award-info":[{"award-number":["#419070600046"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Germ cell tumors (GCTs) often occur in male testes and female ovaries. Extragonadal GCTs account for approximately 2% to 5% of all GCTs and mainly occur in the mediastinum, retroperitoneum, and pineal gland. In this study, we reported a rare case of gastric adenocarcinoma with GCT components. The patient\u2019s serum \u03b1-fetoprotein (AFP) level was higher than normal. Abdominal computed tomography (CT) showed a 10-cm\u2009\u00d7\u200910-cm tumor between the spleen and the bottom of the stomach. Gastric endoscopy indicated an ulcerative lesion extending from the bottom of the stomach to the antrum. Tissue biopsy identified the tumor as an adenocarcinoma. The patient underwent abdominal tumor resection, subtotal gastrectomy, D2 lymphadenectomy, and splenectomy. Postoperative histopathology showed that the tumor was a moderately to poorly differentiated adenocarcinoma. Immunohistochemistry analysis revealed positive staining for AFP, glypican-3, and placental alkaline phosphatase. Gastric adenocarcinoma with GCT components is particularly uncommon and rarely reported. Elevated serum AFP and\/or \u03b2-human chorionic gonadotropin levels, abdominal CT, histopathology, and immunohistochemistry may help diagnose GCTs. Radical surgery resection is the primary treatment method for GCTs. Adjuvant chemotherapy and radiotherapy are effective for advanced GCTs.<\/jats:p>","DOI":"10.1177\/03000605211069202","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T03:47:06Z","timestamp":1641440826000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric adenocarcinoma with germ cell tumor components: a rare case report"],"prefix":"10.1177","volume":"50","author":[{"given":"Xu","family":"Han","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"He","sequence":"additional","affiliation":[{"name":"Operating Theater and Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-7666","authenticated-orcid":false,"given":"Jiannan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, 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