{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:54:52Z","timestamp":1788270892372,"version":"build-2803163510"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the appropriate amount of indocyanine green for bronchial insufflation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green (0.0125 mg\/mL) was insufflated into the subsegmental bronchi in the targeted pulmonary segmental bronchus. The volume of the targeted pulmonary segments was calculated using preoperative computed tomography. Fluorescence spread in the segmental alveoli was visualized using a dedicated near-infrared thoracoscope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The targeted segment was uniformly visualized by indocyanine green fluorescence in 16\/20 (80.0%) cases after insufflating indocyanine green. A receiver operating characteristic curve indicated that the area under the curve was 0.984; the optimal cut-off volume of diluted indocyanine green for insufflation was 8.91% of the calculated targeted pulmonary segment volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The setting for indocyanine green insufflation was optimized for near-infrared fluorescence image-guided anatomical segmentectomy. By injecting the correct amount of indocyanine green, fluorescence-guided anatomical segmentation may be performed more appropriately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060521990202","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:48:00Z","timestamp":1613004480000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-6268","authenticated-orcid":false,"given":"Takashi","family":"Anayama","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan"},{"name":"Center for Photodynamic Medicine, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hirohashi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Orihashi","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"bibr1-0300060521990202","unstructured":"World Health Organization. GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. 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