{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:02:27Z","timestamp":1777726947601,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30470512"],"award-info":[{"award-number":["30470512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate alterations in phase-shift values in the gray matter of patients with amyotrophic lateral sclerosis (ALS) using susceptibility-weighted imaging (SWI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty patients with definite or probable ALS and 19 age- and sex-matched healthy controls were enrolled. SWI was performed using a 3.0 T magnetic resonance imaging scanner. Phase-shift values were measured in corrected phase images using regions of interest, which were placed on the bilateral precentral gyrus, frontal cortex, caudate nucleus, globus pallidus, and putamen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phase-shift values of the precentral gyrus were significantly lower in ALS patients (\u22120.176\u2009\u00b1\u20090.050) than in the control group (\u22120.119\u2009\u00b1\u20090.016) on SWI. The average phase-shift values of the frontal cortex, caudate nucleus, globus pallidus, and putamen in ALS patients (\u22120.089\u2009\u00b1\u20090.023, \u22120.065\u2009\u00b1\u20090.016, \u22120.336\u2009\u00b1\u20090.191, and \u22120.227\u2009\u00b1\u20090.101, respectively) were not significantly different from those in the healthy controls (\u22120.885\u2009\u00b1\u20090.015, \u22120.079\u2009\u00b1\u20090.018, \u22120.329\u2009\u00b1\u20090.136, and \u22120.229\u2009\u00b1\u20090.083, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with healthy controls, ALS patients had a lower phase-shift value in the precentral gyrus, which may be related to abnormal iron overload. Thus, SWI is a potential method for identifying ALS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060521992222","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T23:21:45Z","timestamp":1613344905000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative susceptibility-weighted imaging in amyotrophic lateral sclerosis with 3.0 T magnetic resonance imaging"],"prefix":"10.1177","volume":"49","author":[{"given":"Meng-Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-8013","authenticated-orcid":false,"given":"Zhi-Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital of Chinese PLA 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