{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:21Z","timestamp":1793813901285,"version":"4.6.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"wujieping funding"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sufentanil-induced cough (SIC) is a common complication during anesthesia induction. We explored the recommended sufentanil dose that effectively avoids cough during general anesthesia using a clinical trial to analyze the effective dose (ED)50 and ED95 of sufentanil that avoids cough, hemodynamic fluctuations, and adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On the basis of sufentanil dose, 136 patients (ASA class I\u2013II) were randomly allocated into the following groups: I, 0.1 \u03bcg\/kg; II, 0.3 \u03bcg\/kg; III, 0.5 \u03bcg\/kg; or IV, 1.0 \u03bcg\/kg. The number of coughing incidents, dizziness, panic, and chest tightness within 1 minute after sufentanil injection, and the patient\u2019s heart rate (HR) and blood pressure 5 minutes after intubation were recorded and analyzed. Cough was assessed as follows: none, 0 times; mild, 1 to 2 times\/minute; moderate, 3 to 4 times\/minute; and severe, 5 times\/minute or more.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ED50 and ED95 of cough incidence induced by intravenous sufentanil in patients during general anesthesia induction was 0.332 \u03bcg\/kg and 1.423 \u03bcg\/kg, respectively. The cough rate in group I was lower than the other groups. The incidence of dizziness, panic, chest tightness, hypertension, bradycardia, and tachycardia were not significantly different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The recommended sufentanil dose during general anesthesia induction is 0.1 \u03bcg\/kg.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060521996143","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T23:14:26Z","timestamp":1616022866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Recommended dose of sufentanil during induction of general anesthesia to avoid coughing and drastic hemodynamic fluctuations in patients undergoing surgery"],"prefix":"10.1177","volume":"49","author":[{"given":"Ping","family":"Chen","sequence":"first","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University; Department of Anesthesiology, Yichang Central People\u2019s Hospital, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2719-1009","authenticated-orcid":false,"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University; Department of Anesthesiology, Yichang Central People\u2019s Hospital, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gong","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University; Department of Anesthesiology, Yichang Central People\u2019s Hospital, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Long","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Science, China Three Gorges University; Department of Anesthesiology, Yichang Central People\u2019s Hospital, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"bibr1-0300060521996143","first-page":"35","volume":"44","author":"Maciejewski D.","year":"2013","journal-title":"Anaesthesiol Intensive Ther"},{"key":"bibr2-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-019-00772-x"},{"key":"bibr3-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05249.x"},{"key":"bibr4-0300060521996143","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13010110"},{"key":"bibr5-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(92)90047-L"},{"key":"bibr6-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000112"},{"key":"bibr7-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.08.004"},{"key":"bibr8-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1470-y"},{"key":"bibr9-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198711000-00017"},{"key":"bibr10-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2015.06.012"},{"key":"bibr11-0300060521996143","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.3.234"},{"key":"bibr12-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3274-y"},{"key":"bibr13-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.03.027"},{"key":"bibr14-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-018-4684-4"},{"key":"bibr15-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1007\/s005400170045"},{"key":"bibr16-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d3d641"},{"key":"bibr17-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1159\/000016043"},{"key":"bibr18-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00816-6"},{"key":"bibr19-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPJ05014X"},{"key":"bibr20-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199901000-00067"},{"key":"bibr21-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000204"},{"key":"bibr22-0300060521996143","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199007000-00002"},{"key":"bibr23-0300060521996143","first-page":"e5725","volume":"11","author":"Enten G","year":"2019","journal-title":"Cureus"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060521996143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060521996143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060521996143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:29Z","timestamp":1777459709000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060521996143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1177\/0300060521996143"],"URL":"https:\/\/doi.org\/10.1177\/0300060521996143","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"article-number":"0300060521996143"}}