{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:04:57Z","timestamp":1777727097017,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM), a subtype of chronic inflammatory demyelinating polyneuropathy, is a non-compressive peripheral nerve disorder. Symptoms of MADSAM include asymmetrical weakness and sensory deficits in the distribution of individual peripheral nerves, which are frequently noted in the distal portion of peripheral nerves. MADSAM can be easily misdiagnosed as any of the various compressive peripheral neuropathies. Here, we present a case of MADSAM misdiagnosed as carpal tunnel syndrome (CTS). A 53-year-old woman had bilateral asymmetrical hand weakness (left hand: significant weakness, right hand: slight motor weakness) and a slight weakness of her bilateral lower extremities. Sensory deficit was found on the volar side of her left hand. She had visited many clinics previously and was diagnosed with CTS. However, an electrodiagnostic study performed in our hospital did not identify CTS but indicated a demyelinating peripheral neuropathy in all limbs. On the basis of the patient\u2019s clinical symptoms and laboratory findings, she was diagnosed with MADSAM. When patients exhibit progressive aggravating motor weakness and sensory deficits in more than one distal limb without a specific finding of compressive neuropathy in electrodiagnostic studies, clinicians should consider the possibility of MADSAM.<\/jats:p>","DOI":"10.1177\/0300060521998896","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T21:10:05Z","timestamp":1615497005000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Multifocal acquired demyelinating sensory and motor neuropathy misdiagnosed as carpal tunnel syndrome: a case report"],"prefix":"10.1177","volume":"49","author":[{"given":"Soyoung","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Boudier-Rev\u00e9ret","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-7213","authenticated-orcid":false,"given":"Min Cheol","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"bibr1-0300060521998896","doi-asserted-by":"crossref","unstructured":"Chang MC. Commentary on \u201cUltrasound imaging for a rare cause of postpartum forearm pain: diffuse enlargement rather than focal swelling of the deep branch of the radical nerve,\u201d by Chang et\u00a0al.\n                      Pain Med.\n                      Epub ahead of print 31 Mar 2020. DOI: 10.1093\/pm\/pnaa079.","DOI":"10.1093\/pm\/pnaa079"},{"key":"bibr2-0300060521998896","doi-asserted-by":"crossref","unstructured":"Koike H, Katsuno M. Pathophysiology of chronic inflammatory demyelinating polyneuropathy: insights into classification and therapeutic strategy.\n                      Neurol Ther.\n                      Epub ahead of print 14 May 2020. 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