{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:07:41Z","timestamp":1777727261458,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    Primary central nervous system Hodgkin's lymphoma (CNS-HL) is extremely rare. This current case report describes a 60-year-old male patient that presented with numbness of the left lower extremity and worsening headache. After a full range of investigations and a partial resection of the right cerebellum, external ventricular drainage reservoir placement and cranioplasty, he was diagnosed with primary CNS-HL. The patient was treated with 3 g\/m\n                    <jats:sup>2<\/jats:sup>\n                    methotrexate (intravenous [i.v.], once a day, day 1) and 1 g\/m\n                    <jats:sup>2<\/jats:sup>\n                    cytarabine (i.v., every 12 h, days 2\u2009+\u20093), followed by anti-programmed cell death protein 1 antibodies (200 mg sintilimab, i.v., once a day, day 1, every 3 weeks). After six courses of treatment with intrathecal injections of 50 mg cytarabine (once a day, day 1) and 5 mg dexamethasone (once a day, day 1), there was no residual lesion on cranial magnetic resonance imaging. No significant drug-related adverse events were observed. The patient has been followed up every 3 months and no relapse has occurred.\n                  <\/jats:p>","DOI":"10.1177\/0300060521999533","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:15:09Z","timestamp":1618877709000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary central nervous system Hodgkin's lymphoma: a case report"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-2640","authenticated-orcid":false,"given":"Haiying","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fujian Medical Centre of Haematology, Fujian Provincial Key Laboratory on Haematology, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songsheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fujian Medical Centre of Haematology, Fujian Provincial Key Laboratory on Haematology, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fujian Medical Centre of Haematology, Fujian Provincial Key Laboratory on Haematology, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fujian Medical Centre of Haematology, Fujian Provincial Key Laboratory on Haematology, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fujian Medical Centre of Haematology, Fujian Provincial Key Laboratory on Haematology, Fuzhou, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"bibr1-0300060521999533","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-151563"},{"key":"bibr2-0300060521999533","first-page":"149","volume":"42","author":"Hwang CY","year":"2007","journal-title":"J Korean Neurosurg Soc"},{"key":"bibr3-0300060521999533","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/2.4.239"},{"key":"bibr4-0300060521999533","first-page":"196","volume":"8","author":"Cecyn KZ","year":"2017","journal-title":"J Blood 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