{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:34:17Z","timestamp":1778852057695,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This research received Ipsen diarrhea fund (IDF) support.","award":["RMB 200,000"],"award-info":[{"award-number":["RMB 200,000"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The prevalence of celiac disease (CD) varies geographically and ethnically; however, the prevalence among children in South China remains unknown. We therefore determined the occurrence of CD among Chinese children in South China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples were collected from children and assessed for anti-tissue transglutaminase IgA antibodies (anti-tTG-IgA) and total IgA. Anti-tTG-IgA+ participants underwent human leukocyte antigen (HLA) DQ2\/DQ8 determination. Samples with serum total IgA &lt;0.05\u2009g\/L were also analyzed for anti-tTG-IgG, and for HLA-DQ2\/DQ8 if the values were above borderline. Participants who were anti-tTG-IgA\/IgG+ and HLA-DQ2+ and\/or HLA-DQ8+ underwent small bowel biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 8794 children were enrolled, of whom 479 had chronic unexplained abdominal symptoms. Three (0.034%) children were anti-tTG-IgA+ and ten (0.114%) had serum total IgA &lt;0.05\u2009g\/L, all of whom were anti-tTG-IgG\u2212. The three positive children were all HLA-DQ2+ and\/or HLA-DQ8+. Two underwent gastroscopy, and histopathology of small intestinal biopsy showed duodenal villous blunting in one and increased intraepithelial lymphocytes in the other, neither consistent with a diagnosis of CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed a prevalence of CD autoimmunity of 0.034% and failed to identify any cases of CD, suggesting a low prevalence of CD among children in South China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221076923","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T07:49:51Z","timestamp":1643960991000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Celiac disease may be rare among children in South China"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-0637","authenticated-orcid":false,"given":"Cui-ping","family":"Liang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Jinan University, Guangzhou, China"},{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Lan","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Tang","family":"Gong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Jinan University, Guangzhou, China"},{"name":"Department of Gastroenterology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"bibr1-03000605221076923","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v10.i4.53"},{"key":"bibr2-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000450393.23156.59"},{"key":"bibr3-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081151"},{"key":"bibr4-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1159\/000369518"},{"key":"bibr5-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"bibr6-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0820164"},{"key":"bibr7-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31822a0128"},{"key":"bibr8-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12587"},{"key":"bibr9-03000605221076923","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"bibr10-03000605221076923","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr11-03000605221076923","first-page":"82","volume":"35","author":"Thammarakcharoen 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