{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:41:18Z","timestamp":1791499278495,"version":"4.3.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1103701C and TCVGH-YM1100107"],"award-info":[{"award-number":["TCVGH-1103701C and TCVGH-YM1100107"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The outcomes of patients with acute myeloid leukemia (AML) who relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are poor. However, the risk factors for relapse in this context remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively assessed 84 consecutive adult AML patients who underwent allo-HSCT and achieved complete remission (CR). These patients were dichotomized into non-relapse (n\u2009=\u200958) and relapse (n\u2009=\u200926) groups, and the cumulative relapse rates and associated risk factors were examined. We also examined the treatments for and outcomes of patients with AML relapse after allo-HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-CR status before allo-HSCT and high-risk cytogenetics were significant risk factors for AML relapse in univariate analysis, and non-CR status was also identified as a risk factor in multivariate analysis. The cumulative AML relapse rates after allo-HSCT were significantly higher in patients with non-CR (70.0%) compared with patients with CR (25.6%). Only 2 of the 26 relapsed patients remained alive on the study-censored day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non-CR status before allo-HSCT was a significant risk factor for AML relapse after allo-HSCT. Patients with AML relapse after allo-HSCT had poor outcomes due to a lack of response to salvage remission-induction chemotherapy or treatment-related adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221078466","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T07:28:05Z","timestamp":1645428485000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation: a retrospective study from a single institution"],"prefix":"10.1177","volume":"50","author":[{"given":"Cheng-Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wei","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiann-Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Biostatistics Task Force, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsien","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0368","authenticated-orcid":false,"given":"Chieh-Lin Jerry","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung"},{"name":"Department of Life Science, Tunghai University, Taichung"},{"name":"School of Medicine, Chung Shan Medical University, Taichung"},{"name":"College of Medicine, National Chung Hsing University, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"bibr1-03000605221078466","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.50"},{"key":"bibr2-03000605221078466","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"bibr3-03000605221078466","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.1820"},{"key":"bibr4-03000605221078466","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbmt.2013.08.012","volume":"20","author":"de Lima M","year":"2014","journal-title":"Biol Blood Marrow 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