{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:17:34Z","timestamp":1777727854566,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Cardiac amyloidosis usually presents with diastolic dysfunction, but sometimes systolic dysfunction develops, particularly at its advanced stage. However, the therapeutic strategy for patients with cardiac amyloidosis and systolic dysfunction remains unknown. We report a 77-year-old man who was diagnosed with wild-type cardiac amyloidosis and systolic dysfunction with a left ventricular ejection fraction of 27%. Following 6-month medical therapy of tafamidis 80\u2009mg and neurohormonal blockers (carvedilol 5.0\u2009mg, enalapril 2.5\u2009mg, and spironolactone 25\u2009mg), the left ventricular ejection fraction improved to 55%. Tafamidis-incorporated neurohormonal blocker therapy might be a promising strategy to facilitate cardiac reverse remodeling in patients with cardiac amyloidosis and systolic dysfunction.<\/jats:p>","DOI":"10.1177\/03000605221078484","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T05:09:21Z","timestamp":1659071361000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Combination therapy using tafamidis and neurohormonal blockers for cardiac amyloidosis and a reduced ejection fraction: a case report"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"first","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Izumida","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Hori","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kinugawa","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"bibr1-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12518"},{"key":"bibr2-03000605221078484","first-page":"314","volume":"49","author":"Tian Z","year":"2021","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"bibr3-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"bibr4-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0342"},{"key":"bibr5-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr6-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-20-0062"},{"key":"bibr7-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13411"},{"key":"bibr8-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.05.015"},{"key":"bibr9-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz298"},{"key":"bibr10-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.20-788"},{"key":"bibr11-03000605221078484","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2021.01.007"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221078484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605221078484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221078484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:36Z","timestamp":1777459836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605221078484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/03000605221078484"],"URL":"https:\/\/doi.org\/10.1177\/03000605221078484","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"article-number":"03000605221078484"}}