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At present, the treatment options for SBS are primarily intestinal replacement and rehabilitation. Intestinal rehabilitation mainly includes non-transplantation surgery and intestinal rehabilitation measures. In recent years, intestinal rehabilitation in patients with SBS using nutritional intestinal hormones, especially glucagon-like peptide-2 analogs, has made great progress. Many high-quality studies have provided evidence-based medical findings to support the development of clinical guidelines. This article reviews the latest research advancements regarding the use of glucagon-like peptide-2 analogs (teduglutide, glepaglutide, and apraglutide) in the treatment of SBS.<\/jats:p>","DOI":"10.1177\/03000605221086145","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T05:42:41Z","timestamp":1648446161000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["An updated overview of glucagon-like peptide-2 analog trophic therapy for short bowel syndrome in adults"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-4675","authenticated-orcid":false,"given":"Changzhen","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"bibr1-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.08.017"},{"key":"bibr2-03000605221086145","volume-title":"Surgical Treatment: Evidence-Based and Problem-Oriented[M]","author":"Holzheimer RG","year":"2001"},{"key":"bibr3-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.091108"},{"key":"bibr4-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.011"},{"key":"bibr5-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.07.036"},{"key":"bibr6-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00710.x"},{"key":"bibr7-03000605221086145","first-page":"68","volume":"25","author":"Jian W","year":"2018","journal-title":"Parenteral and Enteral Nutrition"},{"key":"bibr8-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00835"},{"key":"bibr9-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00442-0"},{"key":"bibr10-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005957"},{"key":"bibr11-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1913052"},{"key":"bibr12-03000605221086145","first-page":"G1252","volume":"273","author":"Drucker DJ","year":"1997","journal-title":"Am J Physiol"},{"key":"bibr13-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7752"},{"key":"bibr14-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.1.E134"},{"key":"bibr15-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.08.012"},{"key":"bibr16-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"bibr17-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0070-y"},{"key":"bibr18-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.020"},{"key":"bibr19-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061440"},{"key":"bibr20-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"bibr21-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.69"},{"key":"bibr22-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10092"},{"key":"bibr23-03000605221086145","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000046"},{"key":"bibr24-03000605221086145","unstructured":"NPS Pharmaceuticals. 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