{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:25:24Z","timestamp":1778109924186,"version":"3.51.4"},"reference-count":83,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected over 220 million individuals worldwide, and has been shown to cause increased disease severity and mortality in patients with active cancer versus healthy individuals. Vaccination is important in reducing COVID-19-associated morbidity and mortality. Thus, the aim of this article was to review the existing knowledge on effectiveness, immunogenicity and safety of COVID-19 vaccines in patients with cancer. Fifty-four articles were included following a search of PubMed and Google Scholar databases for studies published between January 2020 and September 2021 that investigated humoral and cell-mediated immune responses following COVID-19 vaccination in patients with cancer. Immunogenicity of vaccines was found to be lower in patients with cancer versus healthy individuals, and humoral immune responses were inferior in those with haematological versus solid cancers. Patient-, disease-, and treatment-related factors associated with poorer vaccine responses should be identified and corrected or mitigated when possible. Consideration should be given to offering patients with cancer second doses of COVID vaccine at shorter intervals than in healthy individuals. Patients with cancer warrant a third vaccine dose and must be prioritized in vaccination schedules. Vaccine adverse effect profiles are comparable between patients with cancer and healthy individuals.<\/jats:p>","DOI":"10.1177\/03000605221086155","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T04:45:26Z","timestamp":1647924326000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["COVID-19 vaccination in cancer patients: a narrative review"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-5673","authenticated-orcid":false,"given":"Suranjith L","family":"Seneviratne","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergy, Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals, Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamodh","family":"Yasawardene","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Widuranga","family":"Wijerathne","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddhika","family":"Somawardana","sequence":"additional","affiliation":[{"name":"Department of Haemato-Oncology, National Cancer Institute, Maharagama, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"bibr1-03000605221086155","unstructured":"World Health Organization.\n                      Weekly epidemiological update on COVID-19 \u2013 21 September 2021: Edition 58\n                      , https:\/\/www.who.int\/publications\/m\/item\/weekly-epidemiological-update-on-covid-19-21-september-2021 (2021, accessed 29 September 2021)."},{"key":"bibr2-03000605221086155","doi-asserted-by":"publisher","DOI":"10.4236\/aid.2020.103014"},{"key":"bibr3-03000605221086155","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trab042"},{"key":"bibr4-03000605221086155","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120957925"},{"key":"bibr5-03000605221086155","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-1536"},{"key":"bibr6-03000605221086155","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1158\/2159-8290.CD-20-0422","volume":"10","author":"Dai M","year":"2020","journal-title":"Cancer Discov"},{"key":"bibr7-03000605221086155","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.02.024"},{"key":"bibr8-03000605221086155","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0773"},{"key":"bibr9-03000605221086155","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30309-0"},{"key":"bibr10-03000605221086155","first-page":"143","volume":"19","author":"Seneviratne SL","year":"2020","journal-title":"International Journal of Progressive Sciences and Technologies"},{"key":"bibr11-03000605221086155","doi-asserted-by":"publisher","DOI":"10.21474\/IJAR01\/10811"},{"key":"bibr12-03000605221086155","doi-asserted-by":"publisher","DOI":"10.4038\/jccp.v51i2.7906"},{"key":"bibr13-03000605221086155","first-page":"17","volume":"36","author":"Seneviratne S","year":"2021","journal-title":"Sri Lankan Family Physician"},{"key":"bibr14-03000605221086155","unstructured":"Public Health England.\n                      SARS-CoV-2 variants of concern and variants under investigation in England: Technical briefing 23\n                      , https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1018547\/Technical_Briefing_23_21_09_16.pdf (17 September 2021. 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