{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:14:54Z","timestamp":1777727694870,"version":"3.51.4"},"reference-count":108,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Coronaviridae is a large family of enveloped, positive-strand RNA viruses that has plagued the world since it was discovered in humans in the 1960s. The recent severe acute respiratory syndrome coronavirus (SARS-CoV)-2 pandemic has already exceeded the number of combined cases and deaths witnessed during previous SARS-CoV and Middle East respiratory syndrome-CoV epidemics in the last two decades. This narrative review focuses on genomic mutations in SARS-CoV-2 and their impact on the severity and progression of COVID-19 in light of reported data in the literature. Notable SARS-CoV-2 mutations associated with open reading frames, the S glycoprotein, and nucleocapsid protein, currently circulating globally, are discussed along with emerging mutations such as those in the SARS-CoV-2 VUI 202012\/01 variant in the UK and other European countries, the 484K.V2 and P.1 variants in Brazil, the B.1.617 variant in India, and South African variants 501Y.V2 and B.1.1.529 (omicron). These variants have the potential to influence the receptor binding domain, host\u2013virus fusion, and SARS-CoV-2 replication. Correlating these mutations with disease dynamics could help us understand their pathogenicity and design appropriate therapeutics.<\/jats:p>","DOI":"10.1177\/03000605221086433","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T08:14:15Z","timestamp":1648628055000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Mutations in the genome of severe acute respiratory syndrome coronavirus 2: implications for COVID-19 severity and progression"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-5739","authenticated-orcid":false,"given":"Ahmed Ali","family":"Al-Qahtani","sequence":"first","affiliation":[{"name":"Department of Infection and Immunity, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Microbiology and Immunology, Alfaisal University, School of Medicine, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"bibr1-03000605221086433","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.020"},{"key":"bibr2-03000605221086433","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26001"},{"key":"bibr3-03000605221086433","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9030186"},{"key":"bibr4-03000605221086433","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2020.017"},{"key":"bibr5-03000605221086433","first-page":"157","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Bio Medica: Atenei Parmensis"},{"key":"bibr6-03000605221086433","unstructured":"Worldometer. 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