{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:43:05Z","timestamp":1784720585530,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Open Fund of State Key Laboratory of Reproductive Medicine of Nanjing Medical University","award":["SKLRM-K202010"],"award-info":[{"award-number":["SKLRM-K202010"]}]},{"name":"Gusu Health Talent Program of Suzhou","award":["GSWS2020068"],"award-info":[{"award-number":["GSWS2020068"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Long non-coding (lnc) RNAs are critical regulators in carcinogenesis. The novel lncRNA DEPDC1 antisense RNA 1 ( DEPDC1-AS1) was recently associated with poor prognosis in triple-negative breast cancer and lung adenocarcinoma. However, its role in regulating the malignant progression of gastric cancer (GC) and its molecular mechanism are unclear. We herein explored the functions of DEPDC1-AS1 in GC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DEPDC1-AS1 expression and prognosis in GC tissues were examined by bioinformatics analysis and quantitative reverse transcription polymerase chain reaction. The DEPDC1-AS1 function in GC cells was explored by the cell counting kit-8 assay, colony formation assay, Transwell assay, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, 5-ethynyl-2\u2032-deoxyuridine-incorporation, and the xenograft tumor model. The DEPDC1-AS1 and human antigen (Hu)R interaction was determined by RNA pull-down and RNA immunoprecipitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DEPDC1-AS1 was overexpressed in GC tissues and cell lines, and associated with a worse prognosis in GC patients. In vitro and in vivo assays showed that DEPDC1-AS1 promoted HGC-27 cell proliferation and migration. Mechanistically, DEPDC1-AS1 served as a scaffold by combining with HuR to target the specific mRNA F11R.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DEPDC1-AS1 plays a crucial role in GC development and progression and is a potential biomarker for the early detection or prognosis of GC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221093135","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T05:47:33Z","timestamp":1650865653000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Long non-coding RNA\n                    <i>DEPDC1-AS1<\/i>\n                    promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R\u2013F11R pathway"],"prefix":"10.1177","volume":"50","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi 214062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi 214062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi 214062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[{"name":"The Central Laboratory of Birth Defects Prevention and Control, Ningbo Women and Children's Hospital, Ningbo 315012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-0753","authenticated-orcid":false,"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215002, 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