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We explored the clinical significance of the widespread application of digital technology for rapid development of the orthodontic\/orthognathic field. The regional acceleratory phenomenon and clear aligners were used to achieve fast and aesthetic tooth movement after surgery. The treatment lasted only 8 months, and the patient was satisfied with the aesthetic results. The results remained stable after 1 year of follow-up. This case report highlights the advantages of combining a digital design and a surgery-first approach to produce accurate, rapid, safe, stable, and fulfilling cosmetic results. The combination of the surgery-first approach and clear aligners can facilitate patient-oriented surgical orthodontic treatment.<\/jats:p>","DOI":"10.1177\/03000605221094524","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T09:00:37Z","timestamp":1651222837000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Combining a digital design-mediated surgery-first approach and clear aligners to treat a skeletal Class III defect for aesthetic purposes: a case report"],"prefix":"10.1177","volume":"50","author":[{"given":"Lei","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China"},{"name":"School of Stomatology of Qingdao University, Qingdao, 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