{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:18:44Z","timestamp":1787617124234,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Mucoepidermoid carcinoma (MEC) is the most common malignant tumour of the salivary gland, primarily involving the parotid gland. Here, the cases of two patients, aged 47 and 67 years, respectively, who underwent surgery for pathologically confirmed Warthin-like MEC of the parotid gland between January 2019 and December 2019 in Anyang Tumour Hospital, are described. In each case, the tumour consisted of epithelial and lymphoid cell components, covered with two or more layers of epithelium, with visible scattered mucous cells, and lymphoid stroma with a large number of lymphocytes and germinal centres formed. Most importantly, the tumours lacked the well-organized, bilayered oncocytic epithelial structure that is characteristic of Warthin\u2019s tumour. Mastermind like transcriptional coactivator 2 ( MAML2) gene rearrangements were identified in the tumour cells using break-apart fluorescence in situ hybridization (FISH) probes, confirming the diagnosis of Warthin-like MEC. Post-operatively, patients have remained disease free for 31 and 27 months, respectively. Warthin-like MEC of the parotid gland is rare and is often misdiagnosed as metaplastic Warthin\u2019s tumour. Diagnosis depends mainly on the unique clinicopathologic features together with FISH analyses.<\/jats:p>","DOI":"10.1177\/03000605221101329","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:04:31Z","timestamp":1658793871000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Warthin-like mucoepidermoid carcinoma of the parotid gland: a clinicopathological analysis of two cases"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-6589","authenticated-orcid":false,"given":"Ruixue","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Pathology, Anyang Tumour Hospital, The Affiliated Anyang Tumour Hospital of Henan University of Science and Technology, Anyang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anyang Tumour Hospital, The Affiliated Anyang Tumour Hospital of Henan University of Science and Technology, Anyang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"bibr1-03000605221101329","unstructured":"Brandwein-Gensler M, Bell D, Inagaki H, et\u00a0al. Mucoepidermoid carcinoma. In: El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg PJ (eds).\n                      WHO Classification of Head and Neck Tumours: WHO Classification of Tumours\n                      . 4th ed, vol 9. Lyon: IARC, 2017, pp.163\u2013164."},{"key":"bibr2-03000605221101329","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2016.6166"},{"key":"bibr3-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0067-0"},{"key":"bibr4-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318258f018"},{"key":"bibr5-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000507"},{"key":"bibr6-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr7-03000605221101329","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13461"},{"key":"bibr8-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917724889"},{"key":"bibr9-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000932"},{"key":"bibr10-03000605221101329","unstructured":"El-Naggar A, Chan J, Grandis J, et al (eds). WHO classification of head and neck tumours: WHO classification of tumours. 4th ed, \nvol 9. \nLyon: \nIARC, 2017, p.189."},{"key":"bibr11-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01159.x"},{"key":"bibr12-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02798-5"},{"key":"bibr13-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.05.026"},{"key":"bibr14-03000605221101329","first-page":"85","volume":"15","author":"Thomaidis V","year":"2006","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"bibr15-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/59515421"},{"key":"bibr16-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01172-w"},{"key":"bibr17-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310409.x"},{"key":"bibr18-03000605221101329","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.1827"},{"key":"bibr19-03000605221101329","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12970"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221101329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605221101329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221101329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:37Z","timestamp":1777459837000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605221101329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/03000605221101329"],"URL":"https:\/\/doi.org\/10.1177\/03000605221101329","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"article-number":"03000605221101329"}}