{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:57:02Z","timestamp":1792601822292,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2221-E-002-186-MY3"],"award-info":[{"award-number":["107-2221-E-002-186-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2221-E-011 -156 -MY2"],"award-info":[{"award-number":["110-2221-E-011 -156 -MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlation between corneal biomechanical properties and topographic parameters using machine learning networks for automatic severity diagnosis and reference benchmark construction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study involving 31 eyes from 31 patients with keratonus. Two clustering approaches were used (i.e., shape-based and feature-based). The shape-based method used a keratoconus benchmark validated for indicating the severity of keratoconus. The feature-based method extracted imperative features for clustering analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were strong correlations between the symmetric modes and the keratoconus severity and between the asymmetric modes and the location of the weak centroid. The Pearson product-moment correlation coefficient (PPMC) between the symmetric mode and normality was 0.92 and between the asymmetric mode and the weak centroid value was 0.75.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed that there is a relationship between the keratoconus signs obtained from topography and the corneal dynamic behaviour captured by the Corvis ST device. Further studies are required to gather more patient data to establish a more extensive database for validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221108100","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T04:56:35Z","timestamp":1656478595000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between corneal dynamic responses and keratoconus topographic parameters"],"prefix":"10.1177","volume":"50","author":[{"given":"Hsi-Yun","family":"Tai","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ji","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Jen","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Jong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-9211","authenticated-orcid":false,"given":"Jia-Yush","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Taiwan University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"bibr1-03000605221108100","doi-asserted-by":"crossref","unstructured":"Kymionis GD, Plaka AD, Kontadakis GA: Clinical signs and differential diagnosis of keratoconus. 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