{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:18:09Z","timestamp":1777727889067,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The UGT1A1*28 polymorphism reduces UGT1A1 enzymatic activity, which may increase the risk of severe toxicity in patients who receive standard-dose irinotecan, such as severe neutropenia and diarrhea. This real-world study assessed the optimal irinotecan dose in terms of efficacy and toxicity in metastatic colorectal cancer (mCRC) patients homozygous for the UGT1A1*28 polymorphism and receiving FOLFIRI plus bevacizumab or cetuximab as first-line therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed toxicity and treatment outcomes in seven mCRC patients who were homozygous for UGT1A1*28 and received FOLFIRI plus bevacizumab or cetuximab, with an initial irinotecan dose of 120\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six of the seven patients tolerated 120\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      irinotecan without requiring dose reductions in subsequent cycles. The overall response and disease control rates were 43.0% (3\/7) and 71.4% (5\/7), respectively. The median progression-free survival and overall survival were 11.0 and 33.0 months, respectively. Only one severe adverse event, grade III neutropenia (2.5%), was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      mCRC patients homozygous for the UGT1A1*28 allele can tolerate irinotecan at an initial dose of 120\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      with favorable oncological outcomes and toxicity profiles. Further prospective studies are warranted to optimize irinotecan-based chemotherapy in these patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221110697","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T02:52:26Z","timestamp":1657680746000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Irinotecan dose reduction in metastatic colorectal cancer patients with homozygous\n                    <i>UGT1A1*28<\/i>\n                    polymorphism: a single-center case series"],"prefix":"10.1177","volume":"50","author":[{"given":"Hsiang-Lin","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Kun","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chih","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Chieh","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Department of Surgery, Kaohsiung Municipal Tatung Hospital, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-3760","authenticated-orcid":false,"given":"Jaw-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung"},{"name":"Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung"},{"name":"Center for Cancer Research, Kaohsiung Medical University, 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