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In addition, evidence that supports the beneficial use of vitamin D as adjuvant treatment of breast cancer is summarized. Vitamin D deficiency is significantly widespread in patients with triple-negative tumors. Several studies have observed a possible modulatory effect of vitamin D or its analogues on the expression of different hormone receptors in breast cancer and increased sensitivity to tamoxifen. Vitamin D possesses anti-inflammatory and immunomodulatory effects in patients with breast cancer, and the mechanism of action of vitamin D in patients with breast cancer is discussed. In conclusion, vitamin D appears to have a beneficial role in the prevention and management of breast cancer, however, large-scale, randomized controlled trials are needed to confirm the effects of vitamin D in breast cancer prevention or treatment.<\/jats:p>","DOI":"10.1177\/03000605221113800","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T01:00:42Z","timestamp":1658883642000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin D: an essential adjuvant therapeutic agent in breast cancer"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-4034","authenticated-orcid":false,"given":"Romany H","family":"Thabet","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Assiut University"},{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, 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