{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:57:42Z","timestamp":1784959062034,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the clinical features, efficacy of antibiotic treatment, and outcome of neonatal listeriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study that included all neonates diagnosed with listeriosis between January 2010 and December 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine male patients and five female patients were analyzed, including 11 preterm and 3 term infants. The mean gestational age was 34\u2009\u00b1\u20092.6 weeks (29\u2009+\u20092\u201340\u2009+\u20092 weeks), and the mean birth weight was 2392\u2009\u00b1\u2009603\u2009g (1370\u20133580\u2009g). The maternal clinical manifestations included fever (13\/14 [92.9%]), meconium-stained amniotic fluid (12\/14 [85.7%]), and intrauterine fetal distress (11\/14 [78.6%]). The neonates presented with fever (14\/14 [100%]), generalized maculopapular rash (7\/14 [50%]), and convulsions (8\/14 [57.1%]). Laboratory tests showed leukocytosis (11\/14 [78.6%]), monocytosis (9\/14 [64.3%]), elevated C-reactive protein levels (13\/14 [92.9%]), and thrombocytopenia (6\/14 [42.9%]). Eight patients had central nervous system involvement, and Listeria monocytogenes was isolated from the blood in all cases. Empiric antibiotic therapy consisted of a combination of third-generation cephalosporins and penicillin or vancomycin. Four patients died, and 10 patients were cured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preterm infants were more susceptible to listeria infection than term infants, with most having multiple organ injuries. Combined antibiotic application improved the effectiveness of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221117207","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T01:37:30Z","timestamp":1661391450000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical features and antibiotic treatment of early-onset neonatal listeriosis"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-9685","authenticated-orcid":false,"given":"Fang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sithany","family":"Nizar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-3403","authenticated-orcid":false,"given":"Xihui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology, the First Affiliated Hospital of Xi\u2019an Jiatong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"bibr1-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182867fa0"},{"key":"bibr2-03000605221117207","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16915121"},{"key":"bibr3-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60233-3"},{"key":"bibr4-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.01.006"},{"key":"bibr5-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2011.035"},{"key":"bibr6-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.11.007"},{"key":"bibr7-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441855"},{"key":"bibr8-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/734814"},{"key":"bibr9-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.06.006"},{"key":"bibr10-03000605221117207","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307059"},{"key":"bibr11-03000605221117207","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr12-03000605221117207","first-page":"897","volume":"41","author":"Neonatal Group of the Pediatrics Society of the Chinese Medical Association","year":"2003","journal-title":"Chin J Pediatr"},{"key":"bibr13-03000605221117207","unstructured":"Shang H, Wang YS, Shen ZY. 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