{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:19:45Z","timestamp":1777727985153,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study aimed to investigate the status of abnormalities in thyroid-related hormones, lipid profile parameters and total proteins in the sera of patients suffering from various metabolic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To analyze the study parameters, enzyme-linked immunosorbent assays, Bradford assays and standard clinical kits and methods were applied. Data were analyzed through the appropriate statistical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all subjects except those with hypotension, thyroid-stimulating hormone, total cholesterol and low-density lipoprotein were elevated, whereas triiodothyronine levels were downregulated. Thyroxin was downregulated in subjects with diabetes and symptomatic thyroiditis but upregulated in patients with hypertension. High-density lipoprotein was upregulated in men who were diabetic only, and total protein was downregulated in those with hypotension only. Hypothyroidism in patients with diabetes, symptomatic thyroiditis and hypertension was correlated with dyslipidemia. In subjects with hypertension, it was correlated with total protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed a link between hypothyroidism, dyslipidemia and total protein in patients with various metabolic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221119656","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:49:58Z","timestamp":1662511798000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders"],"prefix":"10.1177","volume":"50","author":[{"given":"Muniba","family":"Kiran","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Science and Technology, Virtual University of Pakistan, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-6808","authenticated-orcid":false,"given":"Samina","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biochemistry, Biotechnology and Bioinformatics (IBBB), The Islamia University of Bahawalpur, Bahawalpur, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamad Nouman","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Rural Health Center Sardar Pur, Kabirwala-Khanewal, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-121X","authenticated-orcid":false,"given":"Waqas Nazir","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Zahoor","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science and Technology, Virtual University of Pakistan, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Abida","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"bibr1-03000605221119656","doi-asserted-by":"publisher","DOI":"10.21767\/2472-1158.100065"},{"key":"bibr2-03000605221119656","volume":"39","author":"Rasheed H","year":"2009","journal-title":"J Sci Res"},{"key":"bibr3-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.3.F165"},{"key":"bibr4-03000605221119656","doi-asserted-by":"publisher","DOI":"10.3923\/jms.2002.89.94"},{"key":"bibr5-03000605221119656","volume":"21","author":"Jha B","year":"2007","journal-title":"Journal of Institute of Medicine"},{"key":"bibr6-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2016.12.006"},{"key":"bibr7-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1177\/000456329002700204"},{"key":"bibr8-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002193"},{"key":"bibr9-03000605221119656","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"bibr10-03000605221119656","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401105010076"},{"key":"bibr11-03000605221119656","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/439463"},{"issue":"2","key":"bibr12-03000605221119656","first-page":"75","volume":"2","author":"Papazafiropoulou A.","year":"2010","journal-title":"Journal of Clinical Medicine Research"},{"key":"bibr13-03000605221119656","doi-asserted-by":"publisher","DOI":"10.18410\/jebmh\/2016\/1187"},{"key":"bibr14-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0060-7"},{"key":"bibr15-03000605221119656","first-page":"143","volume":"2","author":"Goyal R","year":"2014","journal-title":"Int J Res Appl Natural Soc Sci"},{"key":"bibr16-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg012"},{"key":"bibr17-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01718.x"},{"key":"bibr18-03000605221119656","first-page":"43","volume":"3","author":"Maulik S.","year":"2012","journal-title":"National Journal of Integrated Research in Medicine"},{"key":"bibr19-03000605221119656","doi-asserted-by":"publisher","DOI":"10.37939\/jrmc.v25i4.1682"},{"issue":"12","key":"bibr20-03000605221119656","first-page":"e20316","volume":"13","author":"Sohail R.","year":"2021","journal-title":"Cureus"},{"key":"bibr21-03000605221119656","first-page":"526","volume":"54","author":"Zuberi LM","year":"2004","journal-title":"JPMA The Journal of the Pakistan Medical Association"},{"key":"bibr22-03000605221119656","first-page":"34","volume":"23","author":"Attaullah S","year":"2015","journal-title":"J Of Med Sci"},{"key":"bibr23-03000605221119656","first-page":"37","volume":"25","author":"Siddique S","year":"2010","journal-title":"Punjab Univ J Zool"},{"key":"bibr24-03000605221119656","doi-asserted-by":"publisher","DOI":"10.21065\/19204159.3.33"},{"key":"bibr25-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01718.x"},{"key":"bibr26-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1515\/rjim-2017-0023"},{"key":"bibr27-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-015-0008-3"},{"key":"bibr28-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032143"},{"key":"bibr29-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328082e2ff"},{"key":"bibr30-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02619.x"},{"key":"bibr31-03000605221119656","first-page":"120","volume":"2","author":"Ghooshchi G","year":"2014","journal-title":"Journal of Patient Safety & Quality Improvement"},{"key":"bibr32-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1177\/2050312118756663"},{"key":"bibr33-03000605221119656","first-page":"246","volume":"13","author":"Memon AR SF","year":"2017","journal-title":"Ann PakInst Med Sci"},{"key":"bibr34-03000605221119656","first-page":"287","volume":"10","author":"Zajaczkowska M","year":"2001","journal-title":"Pol Merkur Lekarski"},{"key":"bibr35-03000605221119656","doi-asserted-by":"publisher","DOI":"10.1080\/22953337.1984.11718979"},{"key":"bibr36-03000605221119656","first-page":"9046","volume":"28","author":"Chen Z","year":"2017","journal-title":"Biomedical Research"},{"key":"bibr37-03000605221119656","doi-asserted-by":"publisher","DOI":"10.5455\/2320-6012.ijrms20141185"},{"key":"bibr38-03000605221119656","doi-asserted-by":"publisher","DOI":"10.4103\/1319-6308.156375"},{"key":"bibr39-03000605221119656","volume":"14","author":"Alamdari S","year":"2016","journal-title":"International journal of endocrinology and metabolism"},{"key":"bibr40-03000605221119656","first-page":"61","volume":"2","author":"Kanwar G","year":"2014","journal-title":"IJRANSS"},{"key":"bibr41-03000605221119656","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2016.22.3.146"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221119656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605221119656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221119656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:58Z","timestamp":1777459858000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605221119656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/03000605221119656"],"URL":"https:\/\/doi.org\/10.1177\/03000605221119656","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"article-number":"03000605221119656"}}