{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:21Z","timestamp":1787018781891,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) obstructive sleep apnea (OSA) is associated with the risk of cardiovascular events. Arterial stiffness and carotid artery intima-media thickness (IMT) predict these events, but few relevant studies have been conducted. We compared long-term changes in arterial stiffness and IMT between patients with REM OSA and non-REM (NREM) OSA receiving continuous positive airway pressure (CPAP) or oral appliance (OA) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Newly diagnosed female patients with OSA received CPAP (n\u2009=\u20096) or OA (n\u2009=\u20097). Pulse wave velocity (PWV) and carotid artery ultrasound were performed before and 60 months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no differences in baseline characteristics (mean age: 56.0 vs. 61.3 years; mean body mass index: 22.6 vs. 21.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) between the REM OSA and non-REM OSA groups. The median apnea-hypopnea index was lower in the REM OSA group than in the non-REM OSA group. Increased PWV (12.92\u2009\u00b1\u20091.64 to 14.56\u2009\u00b1\u20092.73\u2009m\/s) and deteriorated glucose metabolism were observed in the REM OSA group after treatment. PWV, IMT, and cardiovascular risk factors were unaffected in the non-REM OSA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Arterial stiffness and glucose metabolism are deteriorated in patients with REM OSA compared with these parameters in patients with non-REM OSA after CPAP or OA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221121941","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T05:57:20Z","timestamp":1663653440000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Long-term outcomes regarding arterial stiffness and carotid artery atherosclerosis in female patients with rapid eye movement obstructive sleep apnea"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-4760","authenticated-orcid":false,"given":"Mayumi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Comprehensive Sleep Medicine, Tokyo Women\u2019s Medical University Hospital (TWMU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shimamoto","sequence":"additional","affiliation":[{"name":"Department of General Medicine, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujio","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Satoya","sequence":"additional","affiliation":[{"name":"Central Clinical Laboratory, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Central Clinical Laboratory, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"},{"name":"Hoshino ENT and Sleep Disordered Breathing Center, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Division of Comprehensive Sleep Medicine, Tokyo Women\u2019s Medical University Hospital (TWMU), Tokyo, Japan"},{"name":"Department of Cardiology, TWMU, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"bibr1-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14426"},{"key":"bibr2-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"bibr3-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043104"},{"key":"bibr4-03000605221121941","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16061068"},{"key":"bibr5-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0537-6"},{"key":"bibr6-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-007-0161-7"},{"key":"bibr7-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02484-2017"},{"key":"bibr8-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-018-1727-2"},{"key":"bibr9-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012592"},{"key":"bibr10-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02635-w"},{"key":"bibr11-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1159\/000228905"},{"key":"bibr12-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1652OC"},{"key":"bibr13-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.1.129"},{"key":"bibr14-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00658.x"},{"key":"bibr15-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.021318"},{"key":"bibr16-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606599"},{"key":"bibr17-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.4366"},{"key":"bibr18-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034410"},{"key":"bibr19-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201601-0088OC"},{"key":"bibr20-03000605221121941","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.1300"},{"key":"bibr21-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12157"},{"key":"bibr22-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1300"},{"key":"bibr23-03000605221121941","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184238"},{"key":"bibr24-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236667"},{"key":"bibr25-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835bdcda"},{"key":"bibr26-03000605221121941","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr27-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147723.52033.9e"},{"key":"bibr28-03000605221121941","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00177"},{"key":"bibr29-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207231"},{"key":"bibr30-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-021-02399-9"},{"key":"bibr31-03000605221121941","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-018-1664-0"}],"container-title":["Journal 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