{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:23:42Z","timestamp":1790270622173,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Paraquat is a non-selective contact herbicide that is absorbed through the digestive tract and skin and can cause multiple organ damage. The toxicokinetics of paraquat poisoning in specific patients are rarely reported. Case 1 was a 76-year-old man who intermittently immersed his perineum in diluted paraquat solution for 3 consecutive days because of eczema of the perineal skin. On admission, the patient\u2019s scrotal skin was severely corroded and his blood paraquat concentration was 0.5\u2009\u03bcg\/mL. He developed severe kidney and lung damage after admission and died on Day 6 of admission. Case 2 was a 23-year-old woman who ingested paraquat during gestational week 36. Her initial blood paraquat concentration was 0.81\u2009\u03bcg\/mL. The patient refused hemoperfusion and a cesarean section. She birthed a baby girl 83 hours after ingesting paraquat. Paraquat concentrations in postnatal maternal blood, fetal blood, umbilical cord blood, and amniotic fluid were 0.19\u2009\u03bcg\/mL, 0.23\u2009\u03bcg\/mL, 0.20\u2009\u03bcg\/mL, and 0.47\u2009\u03bcg\/mL, respectively. The baby died within hours of birth and the mother died of refractory respiratory failure 2 days after delivery. This paper provides clues about paraquat toxicokinetics in specific patient types and indicates that paraquat can be absorbed through the scrotal skin and the placental barrier.<\/jats:p>","DOI":"10.1177\/03000605221122745","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:47:40Z","timestamp":1663894060000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The toxicokinetics of acute paraquat poisoning in specific patients: a case series"],"prefix":"10.1177","volume":"50","author":[{"given":"Longke","family":"Shi","sequence":"first","affiliation":[{"name":"School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China"},{"name":"Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China"},{"name":"Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, 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