{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:00:41Z","timestamp":1787886041839,"version":"build-2784847793"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Meningitis and encephalitis are neurological emergencies requiring rapid diagnosis and treatment. The performance of the FilmArray\u00ae Meningitis\/Encephalitis (ME) panel, a multiplex polymerase chain reaction test, and conventional methods for diagnosing meningitis and encephalitis was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study assessed 20 patients diagnosed with meningitis or encephalitis according to clinical symptoms and laboratory examination findings between January 2018 and December 2019. The results of the FilmArray\u00ae ME panel were compared with those of conventional methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pathogens were identified in 11 (55%) patients using the FilmArray\u00ae ME panel and in nine (45%) patients using conventional methods. The test identified herpes simplex virus type 1 in two patients, herpes simplex virus type 2 in one, varicella-zoster virus in four, Streptococcus pneumoniae in three, and Cryptococcus neoformans in one. Furthermore, additional pathogens were detected (n\u2009=\u20091, S. pneumoniae and n\u2009=\u20091, varicella-zoster virus). The median times to pathogen identification were 2 hours using the FilmArray\u00ae ME panel and 96 hours with conventional methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The sensitivity of the FilmArray\u00ae ME panel for rapidly detecting the most common pathogens was similar to that of conventional methods. Hence, this method could decrease the time to definitive diagnosis and treatment initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221129561","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T07:50:00Z","timestamp":1665388200000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of the FilmArray\u00ae Meningitis\/Encephalitis panel to detect pathogenic microorganisms in cerebrospinal fluid specimens: a single-center retrospective study"],"prefix":"10.1177","volume":"50","author":[{"given":"Makoto","family":"Hara","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-878X","authenticated-orcid":false,"given":"Masaki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-9196","authenticated-orcid":false,"given":"Hideto","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"bibr1-03000605221129561","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63600-3.00019-2"},{"key":"bibr2-03000605221129561","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00070-09"},{"key":"bibr3-03000605221129561","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00730-16"},{"key":"bibr4-03000605221129561","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052228"},{"key":"bibr5-03000605221129561","unstructured":"FilmArray\u00ae Meningitis\/Encephalitis (ME) Panel Instruction Booklet. 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