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Laboratory tests showed a toluidine red unheated serum test titre of 1:128 and Treponema pallidum particle agglutination positivity. Serology for HIV antibodies was repeatedly negative. MS was diagnosed according to established MS diagnostic criteria. The lesions regressed after treatment with 2 400 000 units penicillin G benzathine by intramuscular injection weekly for three consecutive weeks. MS is more frequently associated with HIV-infected patients, which makes this current case more interesting because MS in HIV-negative patients has rarely been reported.<\/jats:p>","DOI":"10.1177\/03000605221131368","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:51:14Z","timestamp":1665449474000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Malignant syphilis in a young woman: A case report"],"prefix":"10.1177","volume":"50","author":[{"given":"Jia-Qi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Lan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-5538","authenticated-orcid":false,"given":"Xiao-Yong","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"bibr1-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1007\/BF01997847"},{"key":"bibr2-03000605221131368","first-page":"11","volume":"9","author":"Neisser A.","year":"1897","journal-title":"Br J Dermatol"},{"key":"bibr3-03000605221131368","first-page":"1313","volume":"41","author":"Yao Q","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"bibr4-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0698-x"},{"key":"bibr5-03000605221131368","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_277_17"},{"key":"bibr6-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1177\/0956462414544162"},{"key":"bibr7-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr8-03000605221131368","author":"Wibisono O","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"bibr9-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14563"},{"key":"bibr10-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1089\/apc.1998.12.921"},{"key":"bibr11-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx139"},{"key":"bibr12-03000605221131368","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7030047"},{"key":"bibr13-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610190076014"},{"key":"bibr14-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.02.024"},{"key":"bibr15-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(01)00249-8"},{"key":"bibr16-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X17731050"},{"key":"bibr17-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-216582"},{"key":"bibr18-03000605221131368","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001155"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221131368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605221131368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221131368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:25Z","timestamp":1777459765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605221131368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1177\/03000605221131368"],"URL":"https:\/\/doi.org\/10.1177\/03000605221131368","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"article-number":"03000605221131368"}}