{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:10:58Z","timestamp":1777727458576,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Acquired haemophilia A (AHA) is a rare haemorrhagic disease characterized by spontaneous extensive subcutaneous haemorrhage and soft tissue haematoma. The activated partial thromboplastin time is significantly prolonged and cannot be corrected by normal plasma. Approximately 50% of AHA patients lack a specific aetiology, so this can easily result in a misdiagnosis. This current case report describes a 27-year-old male that presented with gingival bleeding, haematuria and haematochezia with no obvious cause. At first, it was thought that he might have experienced anticoagulant rodenticide poisoning, but the subsequent anticoagulant rodenticide test was negative. At the same time, the patient was screened for mutations associated with bleeding and coagulation diseases. Two mutations were identified: a p.Y471H mutation the plasminogen activator, tissue type ( PLAT) gene; and a p.Y244Y mutation the serpin family E member 1 ( SERPINE1) gene. It should be noted that patient had no previous history of thrombosis or haemorrhagic disease, which confused the diagnosis. A professional haemophilia research centre provided clarification of the diagnosis when anti-factor VIII antibodies were detected. The patient was treated with 30\u2009mg\/day prednisone orally. Multiple follow-up examinations showed continuous complete remission. No factor VIII antibodies were detected in his blood and coagulation factor VIII increased significantly.<\/jats:p>","DOI":"10.1177\/03000605221132882","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:33:56Z","timestamp":1666658036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis and treatment of acquired factor VIII deficiency: a case report and literature review"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-0123","authenticated-orcid":false,"given":"Yingli","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"},{"name":"Department of Intensive Care Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzi","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Digestive Internal Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-7557","authenticated-orcid":false,"given":"Xiangdong","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangcai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Poisoning and Occupational Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"bibr1-03000605221132882","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.11.005"},{"key":"bibr2-03000605221132882","first-page":"172","volume":"15","author":"Moccia F","year":"2000","journal-title":"Ann Ital Med Int"},{"key":"bibr3-03000605221132882","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04278.x"},{"key":"bibr4-03000605221132882","unstructured":"Heiman M, Gupta S, Khan SS, et\u00a0al. Complete Plasminogen Activator Inhibitor 1 Deficiency. 2017. In: Adam MP, Everman DB, Mirzaa GM, et\u00a0al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2022. 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