{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:28:23Z","timestamp":1786465703171,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Mifepristone has been used to treat endometriosis, but it can cause a constellation of endometrial alterations. Our study investigated the effects of long-term mifepristone on ovarian endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinicopathological changes of ovarian endometriosis in 11 Chinese patients after long-term low-dose mifepristone therapy and compared these alterations with those observed in eutopic endometrium and adenomyosis side-by-side. Immunohistochemistry was applied to investigate estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression in eutopic and ectopic endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nearly all patients had a pelvic mass and elevated serum CA125 levels. The ovarian lesions were grossly solid, cystic-solid, or cystic. They had a grayish\u2013reddish appearance and a fleshy, honeycomb-like cut surface. The ovarian lesions shared morphological features with the uterine endometrium, and they were characterized by dilated, crowding endometrial glands with non-physiological changes. Immunostaining revealed consistent staining for ER and PR and a low Ki67 index in both eutopic and ectopic endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that ovarian endometriosis can mimic an endometrioid borderline tumor after long-term mifepristone administration. Careful histological assessment and related clinical information are critical for the correct interpretation of these rare entities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221134471","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T23:55:30Z","timestamp":1667951730000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-4242","authenticated-orcid":false,"given":"Yongmiao","family":"Pan","sequence":"first","affiliation":[{"name":"Women's Hospital, Hangzhou Normal University (Hangzhou Women's Hospital), Hangzhou, Zhejiang Province, China"},{"name":"Department of General Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"bibr1-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa012"},{"key":"bibr2-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031945"},{"key":"bibr3-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308053290607"},{"key":"bibr4-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31788-8"},{"key":"bibr5-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8140"},{"key":"bibr6-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/9.suppl_1.116"},{"key":"bibr7-03000605221134471","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.10.79"},{"key":"bibr8-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60490-4"},{"key":"bibr9-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg022"},{"key":"bibr10-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.19"},{"key":"bibr11-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.255"},{"key":"bibr12-03000605221134471","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr13-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318251035b"},{"key":"bibr14-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.11.003"},{"key":"bibr15-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.204"},{"key":"bibr16-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2725"},{"key":"bibr17-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1159\/000093130"},{"key":"bibr18-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den393"},{"key":"bibr19-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03081-9"},{"key":"bibr20-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00001"},{"key":"bibr21-03000605221134471","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5305"}],"container-title":["Journal 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