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We analyzed the patient\u2019s clinical characteristics, which indirectly suggested hematogenous spread rather than a cerebrospinal fluid route. Although there are no standard treatments for brain metastasis of NPC, previous studies reported that combined surgery and radiotherapy was a good treatment option, with long survival. Our patient achieved intracranial complete response after the combination of conventional chemoradiotherapy and novel immunotherapy. This treatment option could be useful in future similar cases.<\/jats:p>","DOI":"10.1177\/03000605221147187","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T01:36:40Z","timestamp":1672796200000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Complete response with combined therapy in a patient with brain metastasis from nasopharyngeal carcinoma: case report and literature review"],"prefix":"10.1177","volume":"51","author":[{"given":"Liji","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Affiliated Dongguan People\u2019s Hospital, Southern Medical University, (Dongguan People\u2019s Hospital), Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-3166","authenticated-orcid":false,"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Affiliated Dongguan People\u2019s Hospital, Southern Medical University, (Dongguan People\u2019s Hospital), Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"bibr1-03000605221147187","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"bibr3-03000605221147187","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S144756"},{"key":"bibr4-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02088-w"},{"key":"bibr5-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10179"},{"key":"bibr6-03000605221147187","volume-title":"AJCC cancer staging manual","author":"Edge SB","year":"2010","edition":"7"},{"key":"bibr7-03000605221147187","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.665652"},{"key":"bibr8-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2013.09.004"},{"key":"bibr9-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/405917"},{"key":"bibr10-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009175"},{"key":"bibr11-03000605221147187","first-page":"4142","volume":"12","author":"Zeng Y","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr12-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.03.029"},{"key":"bibr13-03000605221147187","first-page":"195","volume":"55","author":"Lii FN","year":"1995","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"bibr14-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2021.100713"},{"key":"bibr15-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00619-0"},{"key":"bibr16-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1159\/000331188"},{"key":"bibr17-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30495-9"},{"key":"bibr18-03000605221147187","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221147187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605221147187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605221147187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:16Z","timestamp":1777459876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605221147187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/03000605221147187"],"URL":"https:\/\/doi.org\/10.1177\/03000605221147187","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"03000605221147187"}}