{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:39:39Z","timestamp":1784295579846,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Natural Science Foundation of JiangXi Province","award":["20152AC-B20025"],"award-info":[{"award-number":["20152AC-B20025"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81560049"],"award-info":[{"award-number":["No. 81560049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Increasing evidence from randomized controlled trials shows the anti-inflammatory and haemodynamic effects of levosimendan in advanced heart failure (AdHF), however, conflicting results have been reported in some studies. The aim of this study was to estimate the anti-inflammatory and haemodynamic effects of levosimendan on AdHF (registration number: INPLASY202250097).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The MEDLINE, PubMed, ClinicalTrials.com and Cochrane Library databases were systematically searched for studies published in English up to April 2019. Data were extracted from applicable articles. Meta-analyses were performed to assess interleukin (IL)-6, cardiac index, pulmonary artery pressure (PAP) and New York Heart Association (NYHA) functional class efficacy outcomes, following PRISMA 2020 guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11 studies were included (211 patients who received levosimendan and 193 controls). Meta-analyses showed that the levosimendan group displayed significantly reduced IL-6 (standardized mean difference [SMD] \u22121.05; 95% confidence interval [CI] \u22121.44, \u22120.66; I\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200950.9%), improved cardiac index (SMD 0.59; 95% CI 0.29, 0.88; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%); reduced PAP (SMD \u22121.22; 95% CI \u22121.91, \u22120.53; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200989.7%) and improved NYHA functional class (SMD \u22121.66; 95% CI \u22122.27, \u22121.04; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200974.6%) versus controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Levosimendan infusion was beneficial in patients with AdHF, displayed by anti-inflammatory and improved haemodynamic effects, and improved NYHA functional class.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605221148402","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T11:29:08Z","timestamp":1690284548000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The anti-inflammatory and haemodynamic effects of levosimendan on advanced heart failure patients: a meta-analysis of published studies"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-4477","authenticated-orcid":false,"given":"Suzhen","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Image, the Third Hospital of Nanchang, Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 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