{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:03:16Z","timestamp":1789052596090,"version":"build-2803163510"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA237006"],"award-info":[{"award-number":["R01CA237006"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004255"],"award-info":[{"award-number":["I01 BX004255"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge. The overall clinical, immunophenotypic, cytogenetic, and xenotransplantation results suggest a diagnosis of Ph+ T-ALL. The patient was treated with induction chemotherapy including imatinib followed by haploidentical stem cell transplantation and achieved complete remission.<\/jats:p>","DOI":"10.1177\/03000605231156757","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:36:50Z","timestamp":1709213810000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Philadelphia chromosome-positive T-cell acute lymphoblastic leukemia: a case report"],"prefix":"10.1177","volume":"52","author":[{"given":"Qianze","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarneem","family":"Darwish","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyerson","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashirekha","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Gallogly","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-0269","authenticated-orcid":false,"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"},{"name":"Department of Pathology, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"bibr1-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347872"},{"key":"bibr2-03000605231156757","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111621"},{"key":"bibr3-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144790"},{"key":"bibr4-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1159\/000084448"},{"key":"bibr5-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27829"},{"key":"bibr6-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-018192"},{"key":"bibr7-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.30"},{"key":"bibr8-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70377-7"},{"key":"bibr9-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421402"},{"key":"bibr10-03000605231156757","unstructured":"Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia. In. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03007147."},{"key":"bibr11-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr12-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"bibr13-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24579"},{"key":"bibr14-03000605231156757","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12605"},{"key":"bibr15-03000605231156757","first-page":"59","volume":"15","author":"Alshomar A","year":"2020","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"bibr16-03000605231156757","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.584149"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231156757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605231156757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231156757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:21Z","timestamp":1777459761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605231156757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/03000605231156757"],"URL":"https:\/\/doi.org\/10.1177\/03000605231156757","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"article-number":"03000605231156757"}}