{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:01:14Z","timestamp":1777726874833,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Suzhou Youth Science and Technology Project of Rejuvenation Health through Science and Education","award":["KJXW2019014"],"award-info":[{"award-number":["KJXW2019014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the floating, structural, and controlled-release characteristics of a floating poly(lactic-co-glycolic acid) (PLGA)-based controlled-release drug delivery system, and determine the feasibility of this drug delivery system for intravesical instillation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLGA was dissolved in dimethylacetamide, then mixed with IR780 and doxorubicin (DOX) to prepare a drug delivery system capable of solidification and flotation on water at room temperature. Preparations of PLGA, PLGA+IR780, PLGA+DOX, and PLGA+IR780+DOX were formulated. Their floating characteristics in vivo and in vitro were investigated, along with their structural and controlled-release characteristics. Preparations of saline, DOX, and PLGA+IR780+DOX were also formulated; the content of DOX in bladder tissue delivered by each preparation was determined by fluorescence microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PLGA exhibited stable flotation in vivo and in vitro. A honeycomb structure was observed by scanning electron microscopy. When irradiated with a near-infrared laser, IR780 generated heat that vitrified PLGA, allowing controlled release of DOX from the drug delivery system. The PLGA+IR780+DOX preparation achieved the highest content of DOX in bladder tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our floating PLGA-based controlled-release drug delivery system exhibited a honeycomb stabilized structure and achieved controlled release when irradiated by a near-infrared laser, making it an ideal drug delivery system for intravesical instillation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231162065","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:12:22Z","timestamp":1681186342000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Floating poly(lactic-co-glycolic acid)-based controlled-release drug delivery system for intravesical instillation"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-3123","authenticated-orcid":false,"given":"Kai","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Hou","sequence":"additional","affiliation":[{"name":"Center of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, 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