{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:00:54Z","timestamp":1777726854178,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Beta-lactam antibiotics commonly cause immune thrombocytopenia. Cross-reactivity in patients with drug-induced immune thrombocytopenia has rarely been reported. In this study, we describe the case of a 79-year-old man who developed thrombocytopenia after receiving piperacillin\u2013tazobactam for an acute exacerbation of chronic obstructive pulmonary disease, and he was successfully treated with meropenem and cefotiam. However, thrombocytopenia recurred after cefoperazone\u2013sulbactam administration. This indicated that cross-reactivity of platelet-specific antibodies occurred between piperacillin\u2013tazobactam and cefoperazone\u2013sulbactam. However, the responsible drug structures remain unknown, requiring further investigation. Likewise, chemical structure similarities among beta-lactam antibiotics must be examined to determine the risk of immune thrombocytopenia in the clinical setting.<\/jats:p>","DOI":"10.1177\/03000605231162434","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:58:42Z","timestamp":1679885922000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cross-reactivity between piperacillin\u2013tazobactam and cefoperazone\u2013sulbactam in drug-induced immune thrombocytopenia"],"prefix":"10.1177","volume":"51","author":[{"given":"Xiaoyan","family":"He","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"},{"name":"Department of Pharmacy, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"},{"name":"Department of Pharmacy, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, China"},{"name":"Department of Respiratory Medicine, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"},{"name":"Department of Pharmacy, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"},{"name":"Department of Pharmacy, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-3764","authenticated-orcid":false,"given":"Ling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chongqing University Jiangjin Hospital, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"},{"name":"Department of Pharmacy, Central Hospital of Jiangjin District, Chongqing, 725 Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"bibr1-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200208000-00015"},{"key":"bibr2-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697930"},{"key":"bibr3-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-019-01848-3"},{"key":"bibr4-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03378.x"},{"key":"bibr5-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16899"},{"key":"bibr6-03000605231162434","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16295"},{"key":"bibr7-03000605231162434","unstructured":"NCI. 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