{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:11:55Z","timestamp":1790730715200,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To observe the clinical efficacy and safety of the short-term administration of different doses of calcium polystyrene sulfonate in the treatment of hyperkalemia in patients with stage 3\u20135 non-dialysis chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, open, randomized, controlled, single-center clinical observation was conducted. In total, 107 patients were randomly assigned to receive calcium polystyrene sulfonate at 15 (group A) or 30\u2009mg\/day (group B) for 1 week. Patients were assessed on days 0, 3, and 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 3 days of treatment, the serum potassium levels in groups A and B had decreased by 0.68\u2009\u00b1\u20090.46 and 0.75\u2009\u00b1\u20090.43\u2009mmol\/L, respectively. After 7 days, the serum potassium levels in groups A and B had decreased by 0.64\u2009\u00b1\u20090.37 and 0.94\u2009\u00b1\u20090.49\u2009mmol\/L, respectively. Conversely, serum sodium, phosphorus, and calcium levels did not significantly change during the treatment period. Constipation was the most common adverse drug reaction, and no treatment-related serious adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Calcium polystyrene sulfonate administered at a dose of 15 or 30\u2009g\/day can rapidly reduce potassium levels in patients with stage 3\u20135 non-dialysis chronic kidney disease without adverse effects on sodium, phosphorus, or calcium levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231167516","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:55:45Z","timestamp":1681700145000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of calcium polystyrene sulfonate in patients with hyperkalemia and stage 3\u20135 non-dialysis chronic kidney disease: a single-center randomized controlled trial"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-2492","authenticated-orcid":false,"given":"Xia","family":"Wang","sequence":"first","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Song","sequence":"additional","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"bibr1-03000605231167516","doi-asserted-by":"publisher","DOI":"10.1159\/000329511"},{"key":"bibr2-03000605231167516","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2018.11.014"},{"key":"bibr3-03000605231167516","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000320"},{"key":"bibr4-03000605231167516","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0497-z"},{"key":"bibr5-03000605231167516","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"bibr6-03000605231167516","first-page":"419","volume":"29","author":"Li X","year":"2013","journal-title":"Chinese Journal of 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