{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:23:59Z","timestamp":1793683439187,"version":"4.5.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009156","name":"Nantong Science and Technology Bureau","doi-asserted-by":"publisher","award":["JCZ2022122"],"award-info":[{"award-number":["JCZ2022122"]}],"id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"\n Objective<\/jats:title>\n To evaluate the therapeutic effects of high-flow nasal cannula (HFNC) oxygen therapy in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type II respiratory failure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Seventy-two patients with AECOPD and type II respiratory failure were randomly allocated to an HFNC oxygen therapy trial group or a non-invasive positive-pressure ventilator therapy (NIPPV) control group. Their arterial blood gas parameters and comfort, evaluated using a questionnaire, were compared before and after the therapeutic interventions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The PaCO\n 2<\/jats:sub>\n and blood [Formula: see text] concentration of both groups were significantly reduced by the treatments, whereas the pH, PaO\n 2<\/jats:sub>\n and PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n were increased. The PaCO\n 2<\/jats:sub>\n of the experimental group was significantly lower than that of the control group following treatment. The PaO\n 2<\/jats:sub>\n of the experimental group was significantly higher than that of the control group. The tracheal intubation rates of the two groups did not significantly differ. After treatment, all the indices of comfort were rated higher in the HFNC group than in the NIPPV group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n HFNC has a good therapeutic effect in patients with AECOPD and type II respiratory failure. It improves patient comfort and has clinical value.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/03000605231182558","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:55:31Z","timestamp":1687931731000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of high-flow nasal cannula oxygen therapy for patients with acute exacerbation of chronic obstructive pulmonary disease in combination with type II respiratory failure"],"prefix":"10.1177","volume":"51","author":[{"given":"Aiming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong City, Jiangsu Province, 226600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-872X","authenticated-orcid":false,"given":"Yaqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong City, Jiangsu Province, 226600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunguo","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong City, Jiangsu Province, 226600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"bibr1-03000605231182558","first-page":"5501","volume":"39","author":"Liu CHY","year":"2019","journal-title":"Chin J Gerontol"},{"key":"bibr2-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2020.12.010"},{"key":"bibr3-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.004"},{"key":"bibr4-03000605231182558","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S283020"},{"key":"bibr5-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12772"},{"key":"bibr6-03000605231182558","first-page":"2116","volume":"100","author":"Yang SQ","year":"2020","journal-title":"Chin Med J"},{"key":"bibr7-03000605231182558","first-page":"945","volume":"39","author":"Wang JJ","year":"2019","journal-title":"Chin J Crit Care Med"},{"key":"bibr8-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06022-5"},{"key":"bibr9-03000605231182558","first-page":"1041","volume":"37","author":"Chinese Expert Group on Respiratory Medicine","year":"2017","journal-title":"Int J Respir Med"},{"key":"bibr10-03000605231182558","first-page":"251","volume":"33","author":"Guo AM","year":"2010","journal-title":"Chin J Tuberc Respir Dis"},{"key":"bibr11-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"bibr12-03000605231182558","first-page":"349","volume":"43","author":"Yiqi L","year":"2020","journal-title":"J Southwest Med Univ"},{"key":"bibr13-03000605231182558","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2017.1315715"},{"key":"bibr14-03000605231182558","first-page":"38","volume":"6","author":"Liang J","year":"2021","journal-title":"Clin Res Pract"},{"key":"bibr15-03000605231182558","first-page":"1216","volume":"38","author":"Liu F","year":"2018","journal-title":"Int J Resp Med"},{"key":"bibr16-03000605231182558","first-page":"125","volume":"9","author":"Gan WY","year":"2014","journal-title":"China Pract Med"},{"key":"bibr17-03000605231182558","first-page":"116","volume":"40","author":"Chen HM","year":"2019","journal-title":"J Kunming Med Univ"},{"key":"bibr18-03000605231182558","first-page":"989","volume":"40","author":"Yu ZH","year":"2019","journal-title":"J Second Military Med Univ"},{"key":"bibr19-03000605231182558","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2017.0094"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231182558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605231182558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231182558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:19Z","timestamp":1777459699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605231182558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/03000605231182558"],"URL":"https:\/\/doi.org\/10.1177\/03000605231182558","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"article-number":"03000605231182558"}}