{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:03:35Z","timestamp":1777727015129,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Translational Research Grant of NCRCH","award":["2021WWC01"],"award-info":[{"award-number":["2021WWC01"]}]},{"name":"Key R & D projects of Shaanxi Province","award":["2021SF-302"],"award-info":[{"award-number":["2021SF-302"]}]},{"name":"Key R & D projects of Shaanxi Province","award":["2022SF-13"],"award-info":[{"award-number":["2022SF-13"]}]},{"name":"Key R & D projects of Shaanxi Province","award":["2020SF-176"],"award-info":[{"award-number":["2020SF-176"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the impact of natural killer (NK) cells in the graft on the outcome following haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively collected data from patients who had undergone haplo-PBSCT at our centre from January 2019 to November 2021. The percentage of NK cells in stem cell grafts was detected by flow cytometry. Based on the median (range) count of NK cells (1.8 [0.4\u20136.0]\u2009\u00d7\u200910\n                      <jats:sup>8<\/jats:sup>\n                      \/kg), patients were separated into high and low NK cell count groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 96 patients were analysed. Patients were evenly distributed (48 in each group) into high and low NK cell count groups. There was no significant difference in neutrophil and platelet recovery between the two groups. However, the rates of febrile neutropenia, bacterial infection, and invasive fungal disease (IFD) were significantly reduced in the high compared with the low NK cell count group. There was no significant difference in rates of cytomegalovirus (CMV) and Epstein\u2013Barr virus (EBV) infections between groups. There was no significant difference between groups in grades II and above acute graft versus host disease (GVHD), progression-free survival (PFS), or overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A high number of NK cells in the graft may reduce febrile neutropenia, IFD and bacterial infection following haplo-PBSCT but it has no significant effect on aGVHD, PFS, or OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231187932","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T05:09:00Z","timestamp":1690002540000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High levels of NK Cells in graft are associated with reduced febrile neutropenia after haploidentical peripheral blood stem cell transplantation"],"prefix":"10.1177","volume":"51","author":[{"given":"Caili","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaojing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-2774","authenticated-orcid":false,"given":"Xiaoning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Haematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi\u2019an, Shaanxi, China"},{"name":"National Clinical Research Centre for Haematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,22]]},"reference":[{"key":"bibr1-03000605231187932","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.227371"},{"key":"bibr2-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.11.002"},{"key":"bibr3-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.11.026"},{"key":"bibr4-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13537"},{"key":"bibr5-03000605231187932","first-page":"574","volume":"12","author":"Zhang Y","year":"2020","journal-title":"Mol Clin Oncol"},{"key":"bibr6-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"bibr7-03000605231187932","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr8-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"bibr9-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.001"},{"key":"bibr10-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2057396"},{"key":"bibr11-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1177\/1753425918800200"},{"key":"bibr12-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0718-298R"},{"key":"bibr13-03000605231187932","doi-asserted-by":"publisher","DOI":"10.3390\/jof3020025"},{"key":"bibr14-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049028"},{"key":"bibr15-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21508"},{"key":"bibr16-03000605231187932","first-page":"453","volume":"13","author":"Yeral M","year":"2015","journal-title":"Exp Clin Transplant"},{"key":"bibr17-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0665-3"},{"key":"bibr18-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-0037-5"},{"key":"bibr19-03000605231187932","first-page":"1442","volume":"26","author":"We W","year":"2018","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"bibr20-03000605231187932","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017008631"}],"container-title":["Journal of International Medical 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