{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:40:09Z","timestamp":1789800009150,"version":"4.0.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Medical Award Fund","award":["YXJL-2021-0170-0256"],"award-info":[{"award-number":["YXJL-2021-0170-0256"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether S-ketamine affects the Surgical Pleth Index (SPI) during video-assisted thoracoscopic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-four patients undergoing video-assisted thoracoscopic lung lobectomy were enrolled. They were randomly assigned to an S-ketamine group (group S) and an equivalent normal saline group (group N). SPI values were recorded; and pain score on a numerical rating scale (NRS), the consumption of opioids, rescue analgesia, and post-operative nausea and vomiting (PONV) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SPI and heart rate of the S-ketamine group were significantly lower 30 minutes after the start of surgery and at the end. The NRS score was lower in the S-ketamine group 6 and 12 hours postoperatively, but there were no differences in mean blood pressure or the NRS score 24 and 48 hours postoperatively. Rescue analgesia was required less frequently by the S-ketamine group, but the incidence of PONV did not differ between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>S-ketamine was associated with lower intraoperative SPI 30 minutes after the start and at the end of surgery. It also reduced opioid use intraoperatively and the NRS scores 6 and 12 hours postoperatively. Trial registration: Chinese Clinical Trial Registry (ChiCTR2000040012), 18\/11\/2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231198386","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:28:25Z","timestamp":1694420905000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of S-ketamine on the intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic surgery: a single-center randomized controlled clinical trial"],"prefix":"10.1177","volume":"51","author":[{"given":"Xian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesia, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0231-2617","authenticated-orcid":false,"given":"Changdong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, 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