{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:26Z","timestamp":1792787726461,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Central Health Key Project","award":["2020ZD08"],"award-info":[{"award-number":["2020ZD08"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential value of serum hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) concentrations as a biomarker in patients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The enrolled patients were divided into the following four groups: the intensive care unit (ICU) control group (n\u2009=\u200933), infection group (n\u2009=\u200929), septic nonshock group (n\u2009=\u200940), and septic shock group (n\u2009=\u200994). An enzyme-linked immunosorbent assay was used to measure serum HIF-1\u03b1 concentrations on ICU admission. Clinical parameters and laboratory test results were also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum HIF-1\u03b1 concentrations were significantly higher in the infection group, septic nonshock group, and septic shock group than in the ICU control group. Moreover, HIF-1\u03b1 concentrations were associated with a better predictive ability for diagnosing sepsis than the Acute Physiology and Chronic Health Evaluation II score, procalcitonin concentrations, and lactate concentrations. Patients with sepsis and HIF-1\u03b1 concentrations &gt;161.14\u2009pg\/mL had a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum HIF-1\u03b1 concentrations are a useful biomarker for the diagnosis of sepsis and predicting the prognosis of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231202139","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:20:49Z","timestamp":1695990049000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypoxia-inducible factor-1\u03b1 is a biomarker for predicting patients with sepsis"],"prefix":"10.1177","volume":"51","author":[{"given":"Zewen","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-4787","authenticated-orcid":false,"given":"Xiaoting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7571"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5203-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2018.0041"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0183"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001347"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002288"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03039-y"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icz047"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002122"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001694"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000191716.38566.E0"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.726153"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1468087420914714"},{"key":"e_1_3_3_20_2","first-page":"41","article-title":"Prognostic Value of HIF-1\u03b1-Induced Genes in Sepsis\/Septic Shock","volume":"11","author":"Lotsios NS","year":"2023","unstructured":"Lotsios NS, Keskinidou C, Jahaj E, et\u00a0al. Prognostic Value of HIF-1\u03b1-Induced Genes in Sepsis\/Septic Shock. Med Sci (Basel) 2023; 11: 41. 2023\/06\/27. 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