{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:11:04Z","timestamp":1791616264037,"version":"4.3.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Science and Technology Program of Guangzhou","award":["202102020527"],"award-info":[{"award-number":["202102020527"]}]},{"name":"the Science and Technology Project of Guangdong","award":["KTP20190279"],"award-info":[{"award-number":["KTP20190279"]}]},{"name":"the President Foundation of Nanfang Hospital, Southern Medical University","award":["2020C008"],"award-info":[{"award-number":["2020C008"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>We report a case of human herpes virus 6 (HHV-6)- and human herpes virus 7 (HHV-7)-associated choroiditis in an immunocompromised woman. A 42-year-old Chinese woman with a history of acute myelogenous leukemia presented with blurred vision and black floaters in her right eye. Anterior segment examination findings were normal. Ophthalmoscopic examination revealed a subretinal lesion in the superonasal peripapillary region with several punctate hemorrhages. Optical coherence tomography showed a crater-like choroidal protuberance, associated with retinal pigment epithelium rupture and full-thickness retinal edema in the involved area. Indocyanine green angiography demonstrated a broad hypofluorescent lesion in the choroid. The patient was diagnosed with choroiditis. Subsequently, metagenomic next-generation sequencing revealed HHV-6B and HHV-7 DNA in the aqueous humor. Therefore, antiviral therapy was initiated. The patient experienced resolution of all symptoms and signs after treatment with intravenous foscarnet and oral acyclovir. The findings in this case indicate that HHV-6 and HHV-7 can cause ocular infection, particularly in immunocompromised patients.<\/jats:p>","DOI":"10.1177\/03000605231204479","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:17:37Z","timestamp":1698128257000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["HHV-6B- and HHV-7-associated choroiditis secondary to acute myelogenous leukemia: a case report"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-2510","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"bibr1-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2016.09.004"},{"key":"bibr2-03000605231204479","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052364"},{"key":"bibr3-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239220"},{"key":"bibr4-03000605231204479","first-page":"43","volume":"69","author":"Rybka M","year":"2017","journal-title":"Med Dosw Mikrobiol"},{"key":"bibr5-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21268"},{"key":"bibr6-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1032-2"},{"key":"bibr7-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.12.012"},{"key":"bibr8-03000605231204479","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.856533"},{"key":"bibr9-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-014-0016-x"},{"key":"bibr10-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr11-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0113-7"},{"key":"bibr12-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10095"},{"key":"bibr13-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21751"},{"key":"bibr14-03000605231204479","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001015"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231204479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605231204479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231204479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:21Z","timestamp":1777459641000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605231204479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/03000605231204479"],"URL":"https:\/\/doi.org\/10.1177\/03000605231204479","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"article-number":"03000605231204479"}}