{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:30:32Z","timestamp":1781620232717,"version":"3.54.5"},"reference-count":18,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement","award":["978905"],"award-info":[{"award-number":["978905"]}]},{"name":"Lions Cancer Research Fund of Western Sweden"},{"name":"The King Gustav V Jubilee Clinic Cancer Foundation","award":["422"],"award-info":[{"award-number":["422"]}]},{"name":"The Adlerbertska Research Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Pelvic radiotherapy is a powerful treatment for a broad range of cancers, including gynecological, prostate, rectal, and anal cancers. Despite improvements in the delivery of ionizing beams, damage to non-cancerous tissue can cause long-term effects that are potentially severe, affecting quality of life and daily function. There is an urgent need for new strategies to treat and reverse the side effects of pelvic radiotherapy without compromising the antitumor effect. A woman with severe radiation-induced intestinal side effects was treated with the tumor necrosis factor-alpha inhibitor infliximab with a dose of 5\u2009mg\/kg every 4 to 6 weeks. With infliximab treatment, a remarkable improvement in her bowel health was observed. The patient\u2019s late bowel toxicity was reduced from Grade 2 to Grade 0 (RTOG\/EORTC Late Radiation Morbidity Scale). Although it is necessary to proceed cautiously because of the risk of serious side effects from immunosuppressants, our case suggests that infliximab can be used to treat symptoms of chronic bowel dysfunction after radiotherapy.<\/jats:p>","DOI":"10.1177\/03000605231208596","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T23:37:15Z","timestamp":1702337835000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report"],"prefix":"10.1177","volume":"51","author":[{"given":"Amelie","family":"Toft Mor\u00e9n","sequence":"first","affiliation":[{"name":"Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bull","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-2949","authenticated-orcid":false,"given":"Karin","family":"Bergmark","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"bibr1-03000605231208596","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.545832"},{"key":"bibr2-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.08.011"},{"key":"bibr3-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.315"},{"key":"bibr4-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401802"},{"key":"bibr5-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810512.x"},{"key":"bibr6-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181d373bf"},{"key":"bibr7-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"bibr8-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq4473"},{"key":"bibr9-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"bibr10-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.1154"},{"key":"bibr11-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.2.560"},{"key":"bibr12-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr13-03000605231208596","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010439"},{"key":"bibr14-03000605231208596","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082172"},{"key":"bibr15-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50023-4"},{"key":"bibr16-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104691"},{"key":"bibr17-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2018.01.001"},{"key":"bibr18-03000605231208596","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2021.04.009"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231208596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605231208596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605231208596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:42Z","timestamp":1777459662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605231208596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/03000605231208596"],"URL":"https:\/\/doi.org\/10.1177\/03000605231208596","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"article-number":"03000605231208596"}}