{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:19:32Z","timestamp":1788952772718,"version":"build-2803163510"},"reference-count":75,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of antioxidant micronutrient deficiencies in pregnant women with pre-eclampsia and healthy pregnant women, and to assess the relationships between trace element deficiency in pregnancy and the severity of pre-eclampsia in Enugu, Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a secondary analysis of a cross-sectional analytical study of serum concentrations of copper, selenium, zinc, magnesium, and manganese in 81 pregnant women with pre-eclampsia and healthy pregnant women (controls) who were matched for age, gestational age, body mass index, and parity. This study was performed at the University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu. Participants\u2019 sera were analyzed with an atomic absorption spectrophotometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Trace element deficiencies were common and similar between women with pre-eclampsia and controls. However, women with pre-eclampsia were more likely to be deficient in manganese than controls (odds ratio\u2009=\u20092.28, 95% confidence interval: 1.90\u20132.75). Among the micronutrients studied, only manganese concentrations were significantly lower in women without severe symptoms of pre-eclampsia than in those with severe symptoms of pre-eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Micronutrient deficiency is common in pregnant women with pre-eclampsia and in healthy pregnant women in Enugu, Nigeria. Only manganese deficiency is higher in women with pre-eclampsia than in healthy pregnant women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231209159","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T22:37:46Z","timestamp":1699483066000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal antioxidant micronutrient deficiencies among pre-eclamptic women in Enugu, Nigeria: a cross-sectional analytical study"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-1104","authenticated-orcid":false,"given":"Joseph Tochukwu","family":"Enebe","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine\/Teaching Hospital, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril Chukwudi","family":"Dim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Ituku\/Ozalla Campus, Enugu state, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akudo Chidimma","family":"Omeke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine\/Teaching Hospital, Enugu, 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