{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:52:47Z","timestamp":1788457967520,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The study was supported by Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization","award":["2021B1212040007"],"award-info":[{"award-number":["2021B1212040007"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated the pharmacoeconomics of amlodipine combined with benazepril and hydrochlorothiazide combined with benazepril in the treatment of hypertension using a Markov model to provide an evidence-based reference for clinical drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we constructed two types of Markov model using data from the ACCOMPLISH (Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension) trial to dynamically simulate the development of hypertension. The models were subjected to rollback analysis and cohort analysis to obtain the cost and effectiveness of the two drug regimens in preventing stroke and myocardial infarction in hypertensive patients. We conducted sensitivity analysis to determine the stability of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cost-effectiveness of amlodipine combined with benazepril was 66,196.97 RMB with 6.59 QALYs and that of hydrochlorothiazide combined with benazepril was 74,588.50 RMB with 6.46 QALYs. The incremental cost-effectiveness ratio of hydrochlorothiazide\u2009+\u2009benazepril was \u221264,550.23 compared with amlodipine\u2009+\u2009benazepril. The amlodipine\u2009+\u2009benazepril regimen was therefore more cost-effective than hydrochlorothiazide combined with benazepril. The sensitivity analysis results showed that the model was robust.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with the hydrochlorothiazide\u2009+\u2009benazepril treatment regimen, the amlodipine\u2009+\u2009benazepril regimen showed greater economic benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231214921","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T19:40:05Z","timestamp":1703014805000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial"],"prefix":"10.1177","volume":"51","author":[{"given":"Aozi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Clinical Research, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhao","family":"Lin","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Jinan University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-8771","authenticated-orcid":false,"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"bibr1-03000605231214921","unstructured":"World Health Organization. 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