{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:37:40Z","timestamp":1785217060125,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Education Innovation Research Center, Institute of Educational Science, Chinese Academy of Management Sciences","award":["KJCX10326"],"award-info":[{"award-number":["KJCX10326"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the possible mechanism by which curcumin inhibits human prostate cancer (PCa) and castration-resistant prostate cancer (CRPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CRPC cells were treated with curcumin and their viability was assessed by MTT assay and apoptosis was detected by annexinV\/propidium iodide double-staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays. Expression levels of insulin-like growth factor 1 receptor (IGF-1R) were determined by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting. Phosphoinositide 3-kinase (PI3K), Akt, and forkhead box protein O1 (FOXO1) expression and phosphorylation were assessed by western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The highly expressed PCa-related molecule IGF-1R was down-regulated in CRPC cells after curcumin treatment, as determined by RT-qPCR and western blotting. In addition, curcumin inhibited the tumor-related PI3K\/Akt signaling pathway in CRPC cells. Moreover curcumin down-regulated the IGF-1\/PI3K\/Akt signaling pathway in tumors derived from CRPC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrated that curcumin inhibits growth and triggers apoptosis of human CRPC cells via the IGF-1\/PI3K\/Akt pathway, thus providing potential new therapeutic strategies for PCa and CRPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605231220807","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T04:28:36Z","timestamp":1738988916000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1\/PI3K\/Akt pathway"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-251X","authenticated-orcid":false,"given":"Chao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology, The General Hospital of Western Theater Command PLA, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, The General Hospital of Western Theater Command PLA, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, The General Hospital of Western Theater Command PLA, Chengdu, 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