{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:46:39Z","timestamp":1784648799793,"version":"3.55.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Supported by the Research Program of Wuhan Municipal Health and Family Planning Commission","award":["[WH21Z40]"],"award-info":[{"award-number":["[WH21Z40]"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlations between multigene alterations and clinicopathological features in papillary thyroid carcinoma (PTC) samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 111 cytological specimens of thyroid nodules, including 74 PTC samples and 37 benign samples, were analyzed using a 22-gene mutation assay employing next-generation sequencing. Clinicopathological information was retrospectively collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gene alterations were associated with a higher rate of lymph node metastasis (LNM) and thyroid capsular invasion, a lower rate of coexisting Hashimoto's thyroiditis, the classical PTC subtype, and younger age (&lt;45 years). Among the 22 genes tested, the\n                      <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                      mutation rates showed a significant difference between the PTC and benign groups. In the subgroup analysis, younger age (odds ratio\u2009=\u200912.512, 95% confidence interval: 3.126\u201350.087) was an independent risk factor for LNM. In further analyses,\n                      <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                      mutation was significantly associated with LNM in the older subgroup (age\u2009\u2265\u200945 years), suggesting that the\n                      <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                      mutation test has greater value for determining PTC prognosis in the older age group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings will provide a more comprehensive understanding of the relationship between gene mutations and PTC and may contribute to improved PTC management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241233166","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:36:47Z","timestamp":1709887007000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between genetic alterations and clinicopathological features of papillary thyroid carcinomas"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8305-2124","authenticated-orcid":false,"given":"Shixuan","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Jiangxia District (Union Jiangnan Hospital), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Singlera Medical Laboratory, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Jiangxia District (Union Jiangnan Hospital), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Jiangxia District (Union Jiangnan Hospital), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Jiangxia District (Union Jiangnan Hospital), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People's Hospital of Jiangxia District (Union Jiangnan Hospital), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai Singlera Medical Laboratory, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Singlera Medical Laboratory, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Singlera Medical Laboratory, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Singlera Medical Laboratory, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.9.3.317"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30172-6"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0137"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.1153"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(08)15"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1423-5"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP12047.CO"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2089-3"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10230"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2016.0001"},{"key":"e_1_3_5_15_2","first-page":"5393","article-title":"Risk factors influencing the recurrence of papillary thyroid carcinoma: a systematic review and meta-analysis","volume":"7","author":"Guo K","year":"2014","unstructured":"Guo K, Wang Z. 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