{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:32:50Z","timestamp":1780349570166,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Scientific Research Support Fund of Jordan \u2013 Ministry of Higher Education and Scientific Research","award":["MPH\/1\/57\/2021"],"award-info":[{"award-number":["MPH\/1\/57\/2021"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (T\n                      <jats:sub>RM<\/jats:sub>\n                      ). In the present study, we investigated potential functional genetic variations that may predispose MF development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A case\u2013control study was conducted using whole-exome sequencing, with a focus on genes that are essential to T\n                      <jats:sub>RM<\/jats:sub>\n                      function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 21 patients and 19 healthy subjects in the study. Single nucleotide polymorphisms in the following genes were significantly more common in patients than in healthy subjects: GZMB, HLA-DRB1, CD103, and NOTCH1. Moreover, the number of patients carrying single nucleotide polymorphisms in LAG3, NR4A2, and CD26L was significantly greater in the patient group than in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The presence of genetic variations in one or more T\n                      <jats:sub>RM<\/jats:sub>\n                      functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241239034","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:06:28Z","timestamp":1711616788000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes"],"prefix":"10.1177","volume":"52","author":[{"given":"Nour","family":"Almaani","sequence":"first","affiliation":[{"name":"Department of Dermatology, The University of Jordan, Amman, 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