{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:24:49Z","timestamp":1793975089300,"version":"4.8.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of albumin-to-globulin ratio (AGR) in systemic lupus erythematosus (SLE) and its relationship with disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study consecutively selected patients with SLE and healthy controls. Patients were divided into three groups according to the SLE Disease Activity Index 2000 (SLEDAI-2K): group 1 (mild disease activity, SLEDAI-2K\u2009\u2264\u20096), group 2 (moderate disease activity, SLEDAI-2K 7\u201312) and group 3 (severe disease activity, SLEDAI-2K\u2009&gt;\u200912). Predictors of SLE disease activity were analysed by ordinal logistical regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 101 Chinese patients with SLE and 75 healthy Chinese controls were included. Patients with SLE had lower AGR values than healthy individuals, and group 3 patients with SLE displayed lower AGR values than those in group 1, but similar values to group 2. AGR was inversely correlated with SLEDAI-2K (r\u2009=\u2009\u22120.543). Ordinal logistic regression analysis showed that lower AGR (\u03b2\u2009=\u2009\u22121.319) and lower complement C4 (\u03b2\u2009=\u2009\u22121.073) were independent risk factors for SLE disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AGR was decreased in patients with SLE and may be utilized as a useful inflammatory biomarker for monitoring SLE disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241244761","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T07:15:51Z","timestamp":1714029351000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Albumin to globulin ratio (AGR) in systemic lupus erythematosus: correlation with disease activity"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8750-1679","authenticated-orcid":false,"given":"Meng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China"},{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, 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