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A 72-year-old man with severe herpes zoster neuralgia developed maculopapular drug eruption covering 80% to 90% of his total body surface area after 40\u2009days of combined multidrug analgesia. A drug provocation test for pregabalin was positive. The time interval between initiating medication and the onset of the patient\u2019s rash was the longest and he also had the largest area of skin affected compared with patients with a similar condition in previous related reports. Remaining vigilant for possible adverse cutaneous hypersensitivity reactions during treatment is important because of the long-term course of pregabalin treatment for neuropathic pain.<\/jats:p>","DOI":"10.1177\/03000605241245004","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:09:46Z","timestamp":1713452986000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pregabalin-induced delayed cutaneous hypersensitivity reaction occurring after 40 days of use: a case report"],"prefix":"10.1177","volume":"52","author":[{"given":"Mi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kairong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pain Management, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pain Management, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoli","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-2352","authenticated-orcid":false,"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pain Management, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"bibr1-03000605241245004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02999.x"},{"key":"bibr2-03000605241245004","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.09.008"},{"key":"bibr3-03000605241245004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.054"},{"key":"bibr4-03000605241245004","unstructured":"Electronic medicines compendium. 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