{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:14:15Z","timestamp":1777727655091,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Postgraduate Innovation Research and Practice Program of Anhui Medical University","award":["YJS20230013"],"award-info":[{"award-number":["YJS20230013"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Treatment of lower limb ischemia in patients with diabetes is challenging because of the location of the ulcers and the complexity of their pathogenesis. Carbon dioxide fractional laser (CO\n                    <jats:sub>2<\/jats:sub>\n                    FL) therapy in conjunction with tibial periosteum distraction could become a substitute for conventional methods. We herein describe a patient diagnosed with ischemic diabetic foot with a complex ulcer in the upper third of the tibia. Laser irradiation (Deep FX mode with 30 mJ of energy and 10% density) was applied to the entire region of skin below the knee after surface anesthesia, and this treatment was performed twice a week until the ulcer healed. Computed tomography angiography showed successful establishment of a blood supply to the back of the right foot after treatment. Skin grafting was successfully performed, with only a few wounds remaining on the foot 8 months after treatment. The pain score was significantly decreased at the last follow-up. No complications occurred. This case report provides guidance for the performance of CO\n                    <jats:sub>2<\/jats:sub>\n                    FL, a fast, easy, accurate treatment in patients with diabetes. CO\n                    <jats:sub>2<\/jats:sub>\n                    FL can target lower limb arterial occlusive disease accompanied by refractory ulcers, addressing the underlying vascular occlusion and dysfunction as well as promoting microcirculation and wound healing.\n                  <\/jats:p>","DOI":"10.1177\/03000605241253759","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T01:21:35Z","timestamp":1717982495000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of carbon dioxide fractional laser in the management of lower limb ischemia in patients with diabetes: a case report"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-2466","authenticated-orcid":false,"given":"Dan-Lei","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Wei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"bibr1-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"bibr2-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3266"},{"key":"bibr3-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009132"},{"key":"bibr4-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2014.10.002"},{"key":"bibr5-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1583\/14-4692R.1"},{"key":"bibr6-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.003"},{"key":"bibr7-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-016-1337-y"},{"key":"bibr8-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1111\/os.13416"},{"key":"bibr9-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33461"},{"key":"bibr10-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"bibr11-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1117\/1.3103316"},{"key":"bibr12-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0645"},{"key":"bibr13-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"bibr14-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16073"},{"key":"bibr15-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620948351"},{"key":"bibr16-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1177\/1538574420965743"},{"key":"bibr17-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-022-00883-x"},{"key":"bibr18-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3241263"},{"key":"bibr19-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198901000-00038"},{"key":"bibr20-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168937"},{"key":"bibr21-03000605241253759","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120242"}],"container-title":["Journal 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foot"],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/03000605241253759"],"URL":"https:\/\/doi.org\/10.1177\/03000605241253759","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"article-number":"03000605241253759"}}