{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:51:59Z","timestamp":1787849519549,"version":"build-2784847793"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>The aim of this short narrative review was to evaluate the existing literature regarding the clinical use of ketamine among individuals with dementia, especially those with behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, and MEDLINE) databases were searched for abstracts using the search terms \u201cketamine\u201d AND \u201cdementia.\u201d Only articles describing the use of ketamine in individuals with dementia were included. Articles that did not include individuals with dementia, did not use ketamine, were published in a non-English language, primarily described animal studies, or were reviews were excluded. Three case reports met the inclusion criteria. One described the use of subcutaneous ketamine for depression, one described the use of intramuscular ketamine for acute agitation, and one described the use of S-ketamine as anesthesia during electroconvulsive therapy for depression and catatonia. No significant adverse effects were reported in any of the cases. Although the use of ketamine in the treatment of depression and agitation associated with dementia has potential, the current evidence remains limited. High-quality prospective studies are needed to confirm the observations of these case reports before ketamine can be used to treat behavioral disturbances in individuals with dementia.<\/jats:p>","DOI":"10.1177\/03000605241258473","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T23:32:47Z","timestamp":1719012767000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Is there evidence for using ketamine among individuals with dementia?"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7020-1834","authenticated-orcid":false,"given":"Arushi","family":"Kapoor","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-8254","authenticated-orcid":false,"given":"Tanya","family":"Peguero Estevez","sequence":"additional","affiliation":[{"name":"Mount Sinai Beth Israel Hospital, New York, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Chan","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine, Cleveland, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9632-3726","authenticated-orcid":false,"given":"Natsuko","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine, Seton Hill, Greensburg, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-5790","authenticated-orcid":false,"given":"Kyra","family":"Doumlele","sequence":"additional","affiliation":[{"name":"Dartmouth-Hitchcock Medical Center, Lebanon, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Tampi","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Omaha, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"bibr1-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"bibr2-03000605241258473","unstructured":"Medications for memory, cognition, and dementia-related behaviors.\n                      Alzheimer\u2019s Disease and Dementia\n                      , https:\/\/www.alz.org\/alzheimers-dementia\/treatments\/medications-for-memory (accessed 30 July 2023)."},{"key":"bibr3-03000605241258473","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010131"},{"key":"bibr4-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06177-5"},{"key":"bibr5-03000605241258473","doi-asserted-by":"publisher","DOI":"10.58347\/tml.2023.1679b"},{"key":"bibr6-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26641"},{"key":"bibr7-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1176\/appi.pn.2023.07.7.17"},{"key":"bibr8-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.1061"},{"key":"bibr9-03000605241258473","unstructured":"Center for Drug Evaluation and Research. Potential risks associated with compounded ketamine nasal spray. U.S. Food and Drug Administration, https:\/\/www.fda.gov\/drugs\/human-drug-compounding\/fda-alerts-health-care-professionals-potential-risks-associated-compounded-ketamine-nasal-spray (accessed 30 July 2023)."},{"key":"bibr10-03000605241258473","unstructured":"Rosenbaum SB, Gupta V, Patel P, et\u00a0al. Ketamine. [Updated 2023 May 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan- Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470357\/."},{"key":"bibr11-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104762"},{"key":"bibr12-03000605241258473","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint14020025"},{"key":"bibr13-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01280-x"},{"key":"bibr14-03000605241258473","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00612"},{"key":"bibr15-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00230-9"},{"key":"bibr16-03000605241258473","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147421"},{"key":"bibr17-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.04.029"},{"key":"bibr18-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1017\/S104161021700014X"},{"key":"bibr19-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2018.02.006"},{"key":"bibr20-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000334"},{"key":"bibr21-03000605241258473","first-page":"28","volume":"4","author":"Busner J","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"bibr22-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01732-5"},{"key":"bibr23-03000605241258473","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.875246"},{"key":"bibr24-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000235"},{"key":"bibr25-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216002258"},{"key":"bibr26-03000605241258473","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.05.014"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241258473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241258473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241258473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:03Z","timestamp":1777459803000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241258473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/03000605241258473"],"URL":"https:\/\/doi.org\/10.1177\/03000605241258473","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"article-number":"03000605241258473"}}