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The patient was hospitalized with enlarged inguinal lymph nodes, and pathological examination revealed that the lymphoma had transformed into diffuse large B-cell lymphoma. After two cycles of brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (BV-R-CHP) chemotherapy, the patient achieved complete remission. This treatment was followed by autologous hematopoietic stem cell transplantation and lenalidomide maintenance therapy. At the last follow-up, the patient had been in continuous remission for 24 months. This case study suggests that the utilization of BV and R-CHP in conjunction can result in rapid remission, and it can be followed by autologous hematopoietic stem cell transplantation and maintenance therapy with lenalidomide. This treatment approach exhibits potential as a viable option for older individuals with transformed lymphoma.<\/jats:p>","DOI":"10.1177\/03000605241258597","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T07:27:25Z","timestamp":1718263645000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Brentuximab vedotin therapy followed by autologous peripheral stem cell transplantation as a viable treatment option for an older adult with transformed lymphoma: a case report and literature review"],"prefix":"10.1177","volume":"52","author":[{"given":"Jiewen","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Hematology, Shunde Hospital, Southern Medical University (The First People\u2019s Hospital of Shunde), Foshan, Guangdong, 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