{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:19:09Z","timestamp":1780561149156,"version":"3.54.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key project of the Department of Science and Technology of Zhejiang Province","award":["2018C03008"],"award-info":[{"award-number":["2018C03008"]}]},{"name":"Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission","award":["Grant No. 2024KY637"],"award-info":[{"award-number":["Grant No. 2024KY637"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Program","award":["Grant No.2023ZL259"],"award-info":[{"award-number":["Grant No.2023ZL259"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["Grant No. LGF22H090020"],"award-info":[{"award-number":["Grant No. LGF22H090020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>With mechanical thrombectomy (MT), we investigated the prognostic importance of aortic arch calcification (AoAC) and carotid sinus calcification (CaSC) for symptomatic intracerebral hemorrhage (sICH) and poor outcome in acute large artery occlusion (LAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational study, we calculated pre-cranial artery calcification burden (PACB) scores (burden score of AoAC and CaSC) using the AoAC grading scale score plus Woodcock visual score. The outcome measure was sICH per the European Cooperative Acute Stroke Study III definition. A 3-month modified Rankin scale score 3\u20136 was designated as poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with patients who had PACB &lt;3, those with PACB\u2009\u22653 showed substantially higher risks of sICH (odds ratio [OR]\u2009=\u20092.567, 95% confidence interval [CI]\u2009=\u20091.187\u20135.550) and poor outcome (OR\u2009=\u20094.777, 95% CI\u2009=\u20091.659\u201313.756). According to receiver operating characteristic (ROC) curves, adding PACB to the regression model enhanced the predictive value for poor outcome (area under the ROC curve [AUC]: 0.718 vs. 0.519, Z\u2009=\u20092.340) and in patients receiving MT (AUC: 0.714 vs. 0.584, Z\u2009=\u20092.021), independently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Factors related to PACB were consistent with common risk factors of systemic atherosclerosis. Low PACB scores indicated better prognosis. In patients with LAO following MT, PACB was useful in predicting sICH and poor clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241260364","type":"journal-article","created":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T03:51:11Z","timestamp":1722138671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Precranial artery calcification burden: a potential indicator of the clinical outcome of reperfusion in patients with acute large artery occlusion"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-8151","authenticated-orcid":false,"given":"Xiaofeng","family":"Cai","sequence":"first","affiliation":[{"name":"Centre for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-9951","authenticated-orcid":false,"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ningbo First Hospital, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Fan","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longting","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Geng","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmud","family":"Mossa-Basha","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 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