{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:10Z","timestamp":1777727710053,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"crossref","award":["CSTC2020JCYJ-MSXMX1069"],"award-info":[{"award-number":["CSTC2020JCYJ-MSXMX1069"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Joint Medical Scientific Research Project of the Health Commission and Science and Technology Bureau of Wanzhou, Chongqing","award":["wzstc-kw2021001"],"award-info":[{"award-number":["wzstc-kw2021001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24\u2009h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups. The study was retrospectively registered with Research Registry (ID No. researchregistry10304).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 40 patients were included (20 per group). Within 3 days after initiation of treatment, significantly more cases were successfully weaned in the levosimendan group versus control group (eight versus four cases, respectively). Among the eight patients who underwent pulse indicator continuous cardiac output monitoring in the levosimendan group, the global ejection fraction increased 24\u2009h after treatment, and the cardiac function index and cardiac index increased 72\u2009h after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients requiring prolonged mechanical ventilation who have concomitant cardiac dysfunction, levosimendan may be considered to increase the probability of weaning success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241263166","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:52:49Z","timestamp":1722358369000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction"],"prefix":"10.1177","volume":"52","author":[{"given":"Fang","family":"Xiong","sequence":"first","affiliation":[{"name":"Postgraduate School, Jinzhou Medical University, Jinzhou, Liaoning, China"},{"name":"Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 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